| ORIGINAL ARTICLE |
|
| Year : 2013 | Volume
: 17
| Issue : 8 | Page : 526-529 |
|
|
Clinical experience with insulin detemir, biphasic insulin aspart and insulin aspart in people with type 2 diabetes: Results from the Rajasthan cohort of the A 1 chieve study
Akhil Joshi1, Anand Meenawat2, Rajeev Patni3, DC Sharma4, Shashi Panicker5
1 Diabetes Thyroid and Hormone Centre, Kota, Rajasthan, India
2 Satyam Hospital and Research Centre, Jodhpur, Rajasthan, India
3 SDMH and Research Centre, Jaipur, Rajasthan, India
4 Department of Endocrinology, RNT Medical College, Udaipur, Rajasthan, India
5 Sanjeevani Hospital and Diabetes Centre, Jaipur, Rajasthan, India
Correspondence Address:
Akhil Joshi
Diabetes Thyroid and Hormone Centre, Kota
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2230-8210.122116
|
|
|
Background: The A 1 chieve, a multicentric (28 countries), 24-week, non-interventional study evaluated the safety and effectiveness of insulin detemir, biphasic insulin aspart and insulin aspart in people with T2DM (n = 66,726) in routine clinical care across four continents. Materials and Methods: Data was collected at baseline, at 12 weeks and at 24 weeks. This short communication presents the results for patients enrolled from Rajasthan, India. Results: A total of 477 patients were enrolled in the study. Four different insulin analogue regimens were used in the study. Patients had started on or were switched to biphasic insulin aspart (n = 340), insulin detemir (n = 90), insulin aspart (n = 37), basal insulin plus insulin aspart (n = 7) and other insulin combinations (n = 2). At baseline glycaemic control was poor for both insulin naïve (mean HbA 1 c: 8.3%) and insulin user (mean HbA 1 c: 8.4%) groups. After 24 weeks of treatment, both the groups showed improvement in HbA 1 c (insulin naïve: −0.9%, insulin users: −1.2%). Major hypoglycaemic events decreased from 0.5 events/patient-year to 0.0 events/patient-year in insulin naïve group while no change from baseline (1.3 events/patients-year) was observed for insulin users. SADRs were not reported in any of the study patients. Conclusion: Starting or switching to insulin analogues was associated with improvement in glycaemic control with a low rate of hypoglycaemia. |
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
