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Year : 2014  |  Volume : 18  |  Issue : 6  |  Page : 846-849

Treatment of diabetes mellitus-associated neuropathy with vitamin E and Eve primrose

1 Department of Medicine, Lagos State University Teaching Hospital, Ikeja, Lagos State, Nigeria
2 Department of Medicine, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria

Correspondence Address:
Assoc. Prof. Anthonia Okeoghene Ogbera
Department of Medicine, Lagos State University College of Medicine, Ikeja, Lagos
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Source of Support: Strides Vital Nigeria Limited,, Conflict of Interest: None

DOI: 10.4103/2230-8210.140270

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Background: The aim of this report was to assess the efficacy and safety of a combination of vitamin E, an antioxidant, and Eve Primrose in the management of painful diabetes mellitus (DM) neuropathy. Materials and Methods: This was an interventional study that evaluated the efficacy and safety of a combination of vitamin E and Eve Primrose in the management of DM neuropathy. The study was conducted at the Diabetic Centre of the Lagos State University Teaching Hospital, Ikeja. Eighty individuals with type 2 DM who had painful neuropathy were recruited for this study, which took place for a duration of 1 year. The study subjects underwent clinical and biochemical assessment at baseline and were given vitamin E in a dose of 400 mg in combination with Eve Primrose in doses ranging 500-1000 mg/day. They were afterward assessed for relief of symptoms and possible untoward effects after 2 weeks and, thereafter, monthly for 3 months. The main outcome measure was amelioration of symptoms of neuropathy . Results: The mean age and age range of the study subjects were 58.2 years and 37-70 years, respectively. A total of 70 patients (88%) of the study population reported relief from neuropathic pains. Clinical parameters were comparable between the responders and non-responders. One characteristic feature of the non-responders was that they all had vibration perception threshold of ≥25 mV, which was indicative of severe neuropathy. Conclusion: The combination of vitamin E and Eve Primrose is beneficial in the management of mild to moderate diabetic neuropathy.

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