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Year : 2015  |  Volume : 19  |  Issue : 1  |  Page : 174-177

Insulin-derived amyloidosis

1 Department of Medicine, Government Medical College and Hospital, Chandigarh, India
2 Department of Pathology, Vardhman Medical College and Safdarjung Hospital, New Delhi, India
3 Department of Endocrinology, Saket City Hospital, New Delhi, India

Correspondence Address:
Yashdeep Gupta
Department of Medicine, Government Medical College and Hospital, Sector 32, Chandigarh - 160 030
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2230-8210.146879

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Amyloidosis is the term for diseases caused by the extracellular deposition of insoluble polymeric protein fibrils in tissues and organs. Insulin-derived amyloidosis is a rare, yet significant complication of insulin therapy. Insulin-derived amyloidosis at injection site can cause poor glycemic control and increased insulin dose requirements because of the impairment in insulin absorption, which reverse on change of injection site and/or excision of the mass. This entity should be considered and assessed by histopathology and immunohistochemistry, in patients with firm/hard local site reactions, which do not regress after cessation of insulin injection at the affected site. Search strategy: PubMed was searched with terms "insulin amyloidosis". Full text of articles available in English was reviewed. Relevant cross references were also reviewed. Last search was made on October 15, 2014.

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