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BRIEF COMMUNICATION
Year : 2015  |  Volume : 19  |  Issue : 3  |  Page : 426-429

Sodium-glucose cotransporter-2 inhibition and the insulin: Glucagon ratio: Unexplored dimensions


1 Department of Endocrinology, Bharti Hospital and B.R.I.D.E, Karnal, Haryana, India
2 Department of Medicine, Government Medical College and Hospital, Chandigarh, India
3 Senior Medical Advisor, Boehringer Ingelheim, Mumbai, India

Correspondence Address:
Sanjay Kalra
Executive Editor, Indian J Endocrinology and Metabolism, Bharti Hospital and B.R.I.D.E, Karnal - 132 001, Haryana
India
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Source of Support: Dr. Shiva Patil works as Senior Medical Advisor with Boehringer Ingelheim India Private Limited. However, the views expressed by him in this commentary are in his personal capacity as an MD in Pharmacology and not as an employee of Boehringer Ingelheim India., Conflict of Interest: None


DOI: 10.4103/2230-8210.152793

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The sodium-glucose cotransporter 2 (SGLT-2) inhibitors are a novel class of glucose-lowering drugs which act by inhibiting the reabsorption of filtered glucose from the kidneys. Their effect on insulin and glucagon levels has recently been studied but is not fully explained. This communication proposes various hypotheses: A direct effect of SGLT-2 inhibition on the alpha cell receptors, a paracrine or intra-islet mediated effect on alpha cell sensitivity to glucose, and a calorie restriction mimetic action, to explain the impact of these drugs on the insulin glucagon ratio.


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