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Year : 2015  |  Volume : 19  |  Issue : 5  |  Page : 577-596

Place of sulfonylureas in the management of type 2 diabetes mellitus in South Asia: A consensus statement

1 Department of Endocrinology, Bharti Hospital and BRIDE, Karnal, Haryana, India
2 Department of Endocrinology, Post Graduate Medical Institute Hayatabad Medical Complex, Peshawar, Pakistan
3 Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
4 Department of Endocrinology, Pondicherry Institute of Medical Sciences, Puducherry, India
5 Department of Public Health, Bangladesh University of Health Sciences, Dhaka, Bangladesh
6 Department of Endocrinology, Norvic International Hospital, Kathmandu, Nepal
7 Department of Endocrinology, Al-Khaliq Medicare Hospital, Dhaka, Bangladesh
8 Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh
9 Department of Endocrinology, BIRDEM Hospital, Dhaka, Bangladesh
10 Department of Diabetology, Medilink Clinics, Karachi, Pakistan
11 Department of Medicine, Trivuvan University, Kathmandu, Nepal
12 Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
13 South Asian Federation of Endocrine Societies, National Hospital, Dhaka, Bangladesh
14 Department of Clinical Medicines, Diabetes Research Unit, University of Colombo, Colombo, Sri Lanka
15 Department of Endocrinology, Osmania Medical College, Hyderabad, Telangana, India
16 Department of Medicine, Nepal Medical College Teaching Hospital, Kathmandu, Nepal
17 Department of Medicine, MLN Medical College, Allahabad, Uttar Pradesh, India
18 Department of Endocrinology, IPGMER and SSKM Hospital, Kolkata, West Bengal, India
19 Department of Endocrinology and Metabolism, IPGMER, Kolkata, West Bengal, India
20 Department of Medicine and Head, Centre for Diabetes, Endocrinology and Metabolism, UCMS-GTB Hospital, New Delhi, India
21 Department of Endocrinology, BIRDEM, Dhaka, Bangladesh
22 Department of Endocrinology, Kalubowila South Teaching Hospital, Kalubowila, Sri Lanka

Correspondence Address:
Sanjay Kalra
Department of Endocrinology, Bharti Hospital and BRIDE, Karnal, Haryana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2230-8210.163171

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Since their introduction in clinical practice in the 1950's, Sulfonylureas (SUs) have remained the main-stay of pharmacotherapy in the management of type 2 diabetes. Despite their well-established benefits, their place in therapy is inappropriately being overshadowed by newer therapies. Many of the clinical issues associated with the use of SUs are agent-specific, and do not pertain to the class as such. Modern SUs (glimepiride, gliclazide MR) are backed by a large body of evidence, experience, and most importantly, outcome data, which supports their role in managing patients with diabetes. Person-centred care, i.e., careful choice of SU, appropriate dosage, timing of administration, and adequate patient counseling, will ensure that deserving patients are not deprived of the advantages of this well-established class of anti-diabetic agents. Considering their efficacy, safety, pleiotropic benefits, and low cost of therapy, SUs should be considered as recommended therapy for the treatment of diabetes in South Asia. This initiative by SAFES aims to encourage rational, safe and smart prescription of SUs, and includes appropriate medication counseling.

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