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Year : 2015  |  Volume : 19  |  Issue : 5  |  Page : 686-690

High-mix insulins

1 Department of Endocrinology, Bharti Hospital, Karnal, Haryana, India
2 Dubai Diabetes Center, Dubai Health Authority, Dubai, United Arab Emirates
3 Tawam Medical Campus, Johns Hopkins Medicine; Faculty of Medicine, UAE University, Al Ain, Abu Dhabi, United Arab Emirates

Correspondence Address:
Sanjay Kalra
Department of Endocrinology, Bharti Hospital, Karnal, Haryana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2230-8210.163214

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Premix insulins are commonly used insulin preparations, which are available in varying ratios of different molecules. These drugs contain one short- or rapid-acting, and one intermediate- or long-acting insulin. High-mix insulins are mixtures of insulins that contain 50% or more than 50% of short-acting insulin. This review describes the clinical pharmacology of high-mix insulins, including data from randomized controlled trials. It suggests various ways, in which high-mix insulin can be used, including once daily, twice daily, thrice daily, hetero-mix, and reverse regimes. The authors provide a rational framework to help diabetes care professionals, identify indications for pragmatic high-mix use.

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