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| REVIEW ARTICLE |
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| Year : 2016 | Volume
: 20
| Issue : 4 | Page : 546-551 |
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Microvasular and macrovascular complications in diabetes mellitus: Distinct or continuum?
Aastha Chawla1, Rajeev Chawla1, Shalini Jaggi2
1 North Delhi Diabetes Centre, New Delhi, India
2 Sri Balaji Action Medical Institute, New Delhi, India
| Date of Web Publication | 3-Jun-2016 |
Correspondence Address:
Rajeev Chawla
North Delhi Diabetes Centre, Rohini, New Delhi - 110 085
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2230-8210.183480
 Abstract | | |
Diabetes and related complications are associated with long-term damage and failure of various organ systems. The line of demarcation between the pathogenic mechanisms of microvascular and macrovascular complications of diabetes and differing responses to therapeutic interventions is blurred. Diabetes induces changes in the microvasculature, causing extracellular matrix protein synthesis, and capillary basement membrane thickening which are the pathognomic features of diabetic microangiopathy. These changes in conjunction with advanced glycation end products, oxidative stress, low grade inflammation, and neovascularization of vasa vasorum can lead to macrovascular complications. Hyperglycemia is the principal cause of microvasculopathy but also appears to play an important role in causation of macrovasculopathy. There is thought to be an intersection between micro and macro vascular complications, but the two disorders seem to be strongly interconnected, with micro vascular diseases promoting atherosclerosis through processes such as hypoxia and changes in vasa vasorum. It is thus imperative to understand whether microvascular complications distinctly precede macrovascular complications or do both of them progress simultaneously as a continuum. This will allow re-focusing on the clinical issues with a unifying perspective which can improve type 2 diabetes mellitus outcomes.
Keywords: Complications, diabetes, macrovascular, microvascular
How to cite this article:
Chawla A, Chawla R, Jaggi S. Microvasular and macrovascular complications in diabetes mellitus: Distinct or continuum?. Indian J Endocr Metab 2016;20:546-51 |
How to cite this URL:
Chawla A, Chawla R, Jaggi S. Microvasular and macrovascular complications in diabetes mellitus: Distinct or continuum?. Indian J Endocr Metab [serial online] 2016 [cited 2021 Jun 14];20:546-51. Available from: https://www.ijem.in/text.asp?2016/20/4/546/183480 |
| Introduction | |  |
Diabetes mellitus (DM) has routinely been described as a metabolic disorder characterized by hyperglycemia that develops as a consequence of defects in insulin secretion, insulin action, or both. Type 2 diabetes encompasses individuals who have insulin resistance (IR) and usually relative (rather than absolute) insulin deficiency.[1] The pathologic hallmark of DM involves the vasculature leading to both microvascular and macrovascular complications.[2] Chronicity of hyperglycemia is associated with long-term damage and failure of various organ systems mainly affecting the eyes, nerves, kidneys, and the heart.[1]
According to diabetes atlas (7th edition), the global prevalence of diabetes is estimated at 415 million (8.8%), which is predicted to rise to 642 million in next 25 years.[3] In India, there are about 69.2 million people with diabetes and are expected to cross 123.5 million by 2040.[3] Moreover, worldwide approximately 193 million diabetics remain undiagnosed predisposing them to the development of several long-term complications of untreated chronic hyperglycemia.[3] Although intensive glycemic control lowers the incidence and progression of microvascular complications, the morbidity associated with these complications is still increasing.[4] Several landmark studies such as the United Kingdom Prospective Diabetes Study (UKPDS) have demonstrated that strict glycemic control does limit microvascular disease while attempts to improve macrovascular outcomes through glucose-lowering interventions still remain shrouded with controversy. A relative risk (RR) reduction in myocardial infarction (MI) (P = 0.052) has been observed in the 10 years of posttrial follow-up of UKPDS.[5] Similarly, the risk of cardiovascular mortality, nonfatal MI and stroke reduced with pioglitazone in the Prospective Pioglitazone Clinical Trial in Macrovascular Events as compared to placebo group.[6] The action in diabetes and vascular disease: Preterax and Diamicron MR Controlled Evaluation and the Veterans Affairs Diabetes Trial failed to show any significant improvement in cardiovascular risk with the intensification of diabetes therapy.[7],[8] To further complicate matters, in Action to Control Cardiovascular Risk in Diabetes trial the use of intensive therapy for 3.5 years increased mortality but did not significantly reduce major cardiovascular events.[9]
In recent years, much attention has been focused on the management of macrovascular complications such as stroke and acute coronary syndromes. It is well-recognized that vascular complications in a given tissue are often accompanied by evidence of pathology in other vascular territories. A linear relationship between microvascular complications and duration of disease was established by the authors where they documented the presence of microvasculopathy across different age groups in their study in 25–40% of diabetic patients aged >25 years with more than 5 years duration of diabetes.[10] Researchers such as Krentz et al. and Al-Wakeel et al. have observed that both microvascular and macrovascular complications develop simultaneously in diabetes.[11],[12] On the contrary, Matheus and Gomes described the case report of type 1 DM (T1DM) patient with early and aggressive coronary artery disease (CAD) without evidence of nephropathy, retinopathy, or classical risk factors for CAD.[13] Thus, there is not much clarity over whether microvascular complication precedes macrovascular complications or they progress simultaneously.
The present review attempts an insight into this delicate relationship between microvascular and macrovascular complications of diabetes to understand whether they are discrete entities or in continuum with each other. We propose a unique continuum bridging the microvascular and the macrovascular risk which is based on our evidence-based studies consistently over a decade.
| Pathophysiological Basis of Micro Versus Macrovascular Complications | | |
Patients with DM and associated microvascular complications appear particularly at higher risk of accelerated atherosclerosis which ultimately culminates in cerebrovascular and cardiovascular events and premature death.[14] Microvessels are the basic functional unit of the cardiovascular system comprising of arterioles, capillaries, and venules.[2] They differ from macrovessels in both their architecture and cellular components. In contrast to macrovessels supplying blood to organs, microvessels play important roles in maintaining blood pressure and proper nutrient delivery.[2] The microcirculation also has regulatory systems controlling vascular permeability and myogenic responses that can adapt blood flow according to local metabolic needs. Alteration in microvascular function may arise even before overt hyperglycemia and vascular pathologic changes manifest. Diabetes induces pathognomonic changes in the microvasculature, affecting the capillary basement membrane including arterioles in the glomeruli, retina, myocardium, skin, and muscle, by increasing their thickness, leading to the development of diabetic microangiopathy. This thickening eventually leads to abnormality in vessel function, inducing multiple clinical problems such as hypertension, delayed wound healing, and tissue hypoxia. Similarly, neovascularization arising from the vasa vasorum may interconnect macro-and microangiopathy, predict platelet rupture and promote atherosclerosis. The role of microvascular pathology in systemic diabetic complications, including macrovascular atherosclerosis, remains a subject for further debate.[2]
| Intersection of Microvascular and Macrovascular Complications of Diabetes: Evidence-Based Proof of Concept | | |
Diabetic retinopathy
The risk of development of diabetic retinopathy (DR) in patients with (T2DM) has been found to be related to both severities of hyperglycemia and presence of hypertension. Fong et al. attributed approximately 10,000 new cases of blindness to DR in the United States.[15] In India, The Chennai Urban Rural Epidemiology Study (CURES) reported an overall DR prevalence of 17.6% (confidence interval [95% CI]: 15.8–19.5) in the diabetic population.[16] More recently, the Sankara Nethralaya DR Epidemiology and Molecular Genetic Study has estimated an urban prevalence of 18.0% (95% CI: 16.0–20.1) and a rural prevalence of 10.3% (95% CI: 8.53–11.97%) of DR in South India.[17],[18] Similar to this, Aravind Comprehensive Eye Study has reported 10.5% prevalence of DR (in self-reported subjects with diabetes) in the rural South Indian population.[19] A DR prevalence of 21.2% has been reported by Chawla et al. in their cohort of North Indian patients. This study also found a significant association between HbA1c, body mass index, duration of diabetes and microalbuminuria in the development of DR (P = 0.001).[20]
Several studies have explored the association between DR and macrovascular complications. As retinal microvasculature shares embryologic and anatomic characteristics with that of cerebral circulation, researchers have studied retinal abnormalities to provide clues to understand the underlying pathophysiology of different cerebrovascular diseases.[21] In the World Health Organization Multinational Study of Vascular Disease in Diabetes, retinopathy was related to the incidence of MI and death from cardiovascular disease (CVD).[22] In the Atherosclerosis Risk in Communities study, increased incidence of clinical stroke was associated with retinal microvascular abnormalities and generalized arteriolar narrowing.[23] Furthermore, retinopathy was significantly associated with combined stroke events (RR 1.7, 95% CI: 1.0–2.8) in persons without diabetes after controlling for age, sex, and systolic blood pressure. This association was stronger in those with two or more retinal microvascular signs (RR 2.7, CI: 1.5–5.2).[24] Targher et al. followed up 2103 T2DM outpatients for 7 years and found a remarkably increased risk of incident CVD in patients with proliferative/laser-treated retinopathy (hazard ratio 2.08 [1.02–3.7] for men and 2.41 [1.05–3.9] for women), after adjustment of hypertension and advanced nephropathy.[25] Contrary to this, Matheus and Gomes has reported cardiovascular events without any presence of retinopathy.[13]
Diabetic nephropathy
Proteinuria occurs in 15–40% of patients with type 1 diabetes while it ranges from 5 to 20% in patients with T2DM.[26] According to the European Diabetes Prospective Complications Study, the cumulative incidence of microalbuminuria was 12.6% over 7.3 years in patients with T1DM.[26] However, 18 years follow-up study from Denmark reported a prevalence rate of 33% in the T1DM population.[27] Similarly, in the (UKPDS), T2DM patients showed a 2.0% incidence of microalbuminuria per year, which reached up to 25% in 10 years postdiagnosis.[28] The prevalence of diabetic nephropathy was higher in African Americans, Asians, and Native Americans than Caucasians.[26] In India, CURES 45 reported a prevalence of 2.2% for overt diabetic nephropathy and 26.9% for microalbuminuria.[29]
The association of intense control to reduced microvascular complication, as reported by the Diabetes Control and Complications Trial, has emerged as a strong proof of concept for hyperglycemia being an important modifiable risk factor for diabetic nephropathy. A reduction in 10 mm Hg of systolic blood pressure is associated with a 13% decrease in the microvascular complications with minimal risk in patient with a systolic pressure <120 mm Hg.[30] Dyslipidemia with increased low-density lipoprotein (LDL) cholesterol and triglycerides is independently associated with diabetic kidney disease.[31]
The pathogenic mechanisms underlying diabetic nephropathy involve generation of reactive oxygen species (ROS), accumulation of advanced glycation end product (AGE), and activation of intracellular signaling molecules such as protein kinase C (PKC).[32],[33] A strong association between diabetic nephropathy and retinopathy was demonstrated by Arora et al. in 2004–2005 in 50 newly diagnosed patients with diabetes.[34] The direct association between the presence of microalbuminuria and macrovascular complications has also been well-established in many studies.[35] In an observational study, Hägg et al(2013). reported the increased incidence of both cerebral infarction and cerebral hemorrhage in patients with severe DR (SDR) and advanced diabetic nephropathy in 4083 patients with T1DM with 36,680 person-years of follow-up. Both nephropathy and SDR were found to be independently increasing the risk for all subtypes of stroke.[36] The increased incidence of stroke in diabetic nephropathy has also been reiterated in the Pittsburgh Epidemiology of Diabetes Complications study, where overt nephropathy increases the risk of ischemic stroke 4.4-fold (but not the risk for hemorrhagic stroke, probably due to the insufficient number of samples).[36] Retinopathy and macroalbuminuria produce higher rates of cardiovascular events among Chinese patients.[37]
Diabetic neuropathy
Diabetic neuropathy, a life-threatening complication involves both peripheral and autonomic nerves, affecting almost half of the diabetic population.[38] The risk of development of diabetic neuropathy is directly proportional to both the duration and magnitude of hyperglycemia. In addition, some individuals may also possess genetic facets that influence their predisposition in developing such complications.[35] The prevalence of diabetic neuropathy varies from country to country. In India, a high prevalence (29.2%) of diabetic peripheral neuropathy was reported among the North Indian population.[39] Further studies in North Indian region (Lucknow) and North-eastern region (Imphal) revealed a prevalence of 29.2% and 29.0%, respectively, among newly diagnosed diabetic patients (duration <6 months).[40],[41] Chawla et al. reported the prevalence of 15.3% in their study involving 720 North Indian patients from New Delhi.[20]
Although the precise nature of the injury to the peripheral nerves from hyperglycemia is not yet certain, the mechanisms of hyperglycemia-induced polyol pathway, injury from AGEs, and enhanced oxidative stress have been implicated in its pathogenesis. The damage to peripheral nerves may be mediated by effects on nerve tissue or by endothelial injury or vascular dysfunction.[2] Peripheral neuropathy in diabetes appears in several forms depending on the site, manifesting as sensory, focal/multifocal, and autonomic neuropathies. Diabetic neuropathy has resulted in more than 80% amputations after foot ulceration or injury.[35]
A study conducted by Miguel et al. demonstrated a significant correlation between diabetic neuropathy and the existence of one or more macrovascular complications showing that diabetic patients with peripheral neuropathy presented with significantly higher rates of cardiac events and peripheral vascular disease (PVD) than diabetic patients without neuropathy. Strokes were also numerically higher in the neuropathy group.[42] Chawla et al. in 2011–2012 demonstrated an association between diabetic neuropathy and development of DR and microalbuminuria in 855 patients.[43] Diabetic cardiac autonomic neuropathy have been found to have a strong co-association with DR (22% vs. 14.3%), diabetic neuropathy (14% vs. 6.8%), and poor glycemic control.
Hence, it is recommended to evaluate autonomic nervous system function at the time of T2DM diagnosis and annually thereafter.[44] Chawla et al. established a positive correlation between autonomic neuropathy and peripheral neuropathy (P = 0.00014); however, the further association between autonomic neuropathy and PVD failed to reach statistical significance.[45] In addition, a direct relationship of lower extremity arterial disease (LEAD) with T2DM was also documented by Chawla et al. They found symptoms of peripheral vascular insufficiency or weak peripheral vessels in 13.8% of patients with foot Doppler confirmed the prevalence of LEAD in 7.4% of patients.[46] The authors validated and advocate the use of neuropathy symptoms score and neuropathy disability score in the clinical and bedside diagnosis of peripheral neuropathy.[47]
| Common Pathways for Development of Both Micro and Macrovascular Complications | | |
Advanced glycation products
AGEs are a heterogeneous group of molecules formed by the nonenzymatic glycation of plasma proteins causing a disruption in their normal functioning by altering their molecular conformation, disrupting enzyme activity, and interfering with receptor functioning. AGEs accumulate in different types of cells and affect their extracellular and intracellular structure and function by cross-linking not only with proteins but also lipids and nucleic acids contributing to a variety of diabetic complications.[48] AGEs crosslink with plasma membrane-localized receptors for AGEs (RAGE) leading to up-regulation of transcription factors such as nuclear factor-κB and its target genes, release of pro-inflammatory molecules and free radicals. Soluble AGEs activate monocytes, and AGEs in the basement membrane inhibit monocyte migration. AGE-bound RAGE increases endothelial permeability to macromolecules. AGEs block nitric oxide activity in the endothelium and cause the production of ROS.[49]
Further, AGEs modify LDL particles and together with vascular damage accelerate atherosclerosis.[50] Kalousová et al. found significant elevation of AGE in patients with T2DM as compared to both healthy (5.11 ± 1.15 × 103 AU/g vs. 4.08 ± 0.71 × 103 AU/g, P < 0.001) as well as T1DM patients (4.14 ± 0.86 × 103 AU/g, P < 0.005).[51] Kilhovd et al. demonstrated a significant increase in the levels of AGEs in patients with T2DM compared with nondiabetic control subjects (7.4 [4.4–10.9] vs. 4.2 [1.6–6.4] U/ml, P < 0.0001). Besides, they also found elevated levels of AGE in patients with coronary heart disease (CHD) than those of without CHD (8.1 [6.4–10.9] vs. 7.1 [3.5–9.8] U/ml, P = 0.03) in patients with T2DM.[52]
Oxidative stress
Oxidative stress, caused by the overproduction of ROS plays an important role in the activation of other pathogenic pathways involved in diabetic complications, including elevated polyol pathway activity, nonenzymatic glycation, and PKC levels which in turn lead to the development of micro-and macrovascular complications.[53] It also inactivates two critical anti-atherosclerotic enzymes, endothelial nitric oxide synthase, and prostacyclin synthase.[54] Hyperglycemia promotes the formation of ROS, which interacts with both deoxyribonucleic acid (DNA) and proteins, causing cellular damage, especially targeting mitochondrial DNA. A study on the human retinal endothelial cell (EC) demonstrated very early mitochondrial DNA damage with hyperglycemia-induced overproduction of ROS.[55] ROS-mediated cellular damage may be a form of pathologic “memory” in the microvasculature that persists even after glucose normalization. Several experimental evidences point to mitochondrial superoxide overproduction as the major culprit in the development of metabolic abnormalities in diabetics.[56] IR induces mitochondrial ROS production from free fatty acids and inhibits anti-atherosclerotic enzymes causing atherosclerosis and cardiomyopathy in T2DM patients. In subjects without diabetes or impaired glucose tolerance, those in the highest quintile of IR had a 2.0-fold increase in CVD risk compared to those in the lowest quintile after adjusting several known cardiovascular risk factors, including LDL, triglycerides, high-density lipoprotein, systolic blood pressure, and smoking.[57]
The other pathways implicated in diabetic complications such as AGE formation, PKC activation, increased polyol flux, and hexosamine formation are also linked to oxidative stress in promoting macrovascular complications through multiple mechanisms. Increased glucose concentrations can activate nuclear factor-κB, a key mediator that regulates multiple pro-inflammatory and pro-atherosclerotic target genes in vascular smooth muscle cells (VSMCs), ECs, and macrophages.[55] Hyperglycemia itself stimulates oxidative stress, which indeed acts as a driving force in accelerated atherosclerosis.
Low-grade inflammation
Inflammation has been recognized as one of the potent risk factors in both atherosclerosis and T2DM. Vascular cells encounter many early pathologic changes in response to hyperglycemia, causing a loss of nonadhesive property and adhesion of monocyte to ECs, which is an early step in atherogenesis. Hyperglycemia has been reported to provoke monocyte adhesion to arterial ECs.[58] The association between hyperglycemia and AGEs with oxidative stress is manifested as both can stimulate EC production of superoxide [Figure 1]. Glucose also activates matrix-degrading enzyme metalloproteinase which causes plaque rupture and arterial remodeling as well as VSMC proliferation, migration and altered activity. The role of increased level of tumor necrosis factor alpha in the development of IR is well-documented. IR itself has inflammatory action as described above. The levels of several other inflammatory markers such as C-reactive protein, fibrinogen, plasminogen activator inhibitor I, and interleukine-6 have been shown to increase with the onset of diabetes. Monocyte activation has been documented in the presence of high glucose with induction of inflammatory mediators such as PKC and nuclear factor-κB promoting oxidative stress.[59] | Figure 1: Insulin resistance and hyperglycemia drive the atherosclerotic process
Click here to view |
Neovascularization of vasa vasorum
The proliferation of vasa vasorum is associated with increased plaque burden, which subsequently promotes atherosclerosis.[60] Many cellular processes such as inflammation, plaque perfusion and concomitant intra-plaque hemorrhage are critical during the development of atherosclerotic plaques and are linked with vasa vasorum proliferation. Neovascularization develops by the growth from both adventitial layer (outward) and arterial lumen (inward) toward the intima.[61] In T2DM, plaque rupture is associated with increased angiogenesis, and diabetic atherosclerosis is further accelerated by neovasculature microangiopathy.[62] The initial angiogenic response in the adventitial vasa vasorum, an important component of homeostatic mechanisms, appears to be stimulated by hypoxia through identification of increased hypoxia-inducible factor and vascular endothelial growth factor (VEGF) action.[63]
VEGF, a multifunctional cytokine, also contributes to microvascular complications by increasing the vascular permeability to macromolecules, monocyte chemotaxis, and tissue factor production.[64] Up-regulation of VEGF is also reported in experimental diabetic kidney disease models. However, contrary to this, VEGF treatment has been shown to restore microcirculation in the vasa nervorum and limit diabetic neuropathy as demonstrated by rodent VEGF gene transfer experiment.[2] In the eye, a neurotropic factor-pigment epithelium-derived factor (PEDF) may offset VEGF action by its potent angiogenic inhibition.[65] PEDF level is decreased in proliferative DR, whereas VEGF levels are increased. Decreased PEDF levels may also likely contribute to diabetic nephropathy. Other growth factors such as insulin-like growth factor 1, basic fibroblast growth factor, and hepatocyte growth factor may foster proliferative retinopathy.[66]
| Microvascular and Macrovascular Complications-Continuum or Separate: The Debate Continues | | |
[Figure 2]
Heart involvement in diabetes may not be only a macrovascular disease where there is Orchestra of contributing factors to the development of diabetic cardiomyopathy concerning fatty acid and glucose complex structural macrovascular derangements such as hypertrophy and loss of function due to glycation but also a microvascular involvement following “common soil” hypothesis of diabetes complications. Atherosclerosis in large arteries as well as cardiomyopathy in diabetes a microvascular component may go hand in hand.[67]
Therefore, changes in small arteries and capillaries are not responsible for only microvascular long-term complications in patients with diabetes (retinopathy, nephropathy, and neuropathy) but also for other manifestations of heart disease in diabetes.
This review highlights the need for implementing programs for early detection, screening, and awareness to mitigate the burden of managing the complications.
Good blood glucose control improves microvascular disease and should be implemented early and maintained for the optimum length of time. Appropriate controls of blood pressure as well as dyslipidemia are extremely important in macrovascular disease prevention besides glycemic control. Patients with microvascular complications appear particularly prone to accelerated atherosclerosis and premature death. Neovascularization arising from the vasa vasorum may interconnect macro-and microangiopathy.
A clearer picture on differing responses to therapeutic interventions could lead to better management and improve T2DM outcomes not only regarding microvascular but also macrovascular complications as well. Further systematic research on the above interlinking hypothesis will help us get more clarity whether microvascular complications precede macrovascular complications or they are two ends of the same spectrum of disease existing in continuum.
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
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OBSERVATIONAL STUDY EVALUATING ASSOCIATION OF TYPE 2 DIABETES MELLITUS AND THYROID DYSFUNCTION |
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| Elizabeth Jacob,Vivek Koshy Varghese,Tittu Oommen | | Journal of Evidence Based Medicine and Healthcare. 2018; 5(31): 2285 | | [Pubmed] | [DOI] | | | 224 |
Enhanced calcium entry via activation of NOX/PKC underlies increased vasoconstriction induced by methylglyoxal |
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| Basma G. Eid,Alaa T. Abu-Sharib,Hany M. El-Bassossy,Khadijah Balamash,Sergey V. Smirnov | | Biochemical and Biophysical Research Communications. 2018; | | [Pubmed] | [DOI] | | | 225 |
Neuroprotective Effect of Hydroxytyrosol in Experimental Diabetic Retinopathy: Relationship with Cardiovascular Biomarkers |
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| José Antonio González-Correa,María Dolores Rodríguez-Pérez,Lucía Márquez-Estrada,Juan Antonio López-Villodres,José Julio Reyes,Guillermo Rodriguez-Gutierrez,Juan Fernández-Bolaños,José Pedro De La Cruz | | Journal of Agricultural and Food Chemistry. 2018; 66(3): 637 | | [Pubmed] | [DOI] | | | 226 |
Association of carotid intima-media thickness with exercise tolerance test in type 2 diabetic patients |
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| Ali Momeni,Abdolmajid Taheri,Maryam Mansuri,Ali Bazdar,Morteza Sedehi,Masoud Amiri | | IJC Heart & Vasculature. 2018; 21: 74 | | [Pubmed] | [DOI] | | | 227 |
Association of ACE2 polymorphisms with susceptibility to essential hypertension and dyslipidemia in Xinjiang, China |
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| Yizhi Pan,Tianyi Wang,Yanfang Li,Tianwang Guan,Yanxian Lai,Yan Shen,Abudurexiti Zeyaweiding,Tutiguli Maimaiti,Fang Li,Haiyan Zhao,Cheng Liu | | Lipids in Health and Disease. 2018; 17(1) | | [Pubmed] | [DOI] | | | 228 |
Increased Prevalence of Type 2 Diabetes–Related Complications in Combined Type 2 Diabetes and Sickle Cell Trait |
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| Sarah C. Skinner,Mor Diaw,Vincent Pialoux,Maïmouna Ndour Mbaye,Pauline Mury,Philomène Lopez,Delphine Bousquet,Fatou Gueye,Demba Diedhiou,Philippe Joly,Céline Renoux,Djiby Sow,Saliou Diop,Brigitte Ranque,Agnès Vinet,Abdoulaye Samb,Nicolas Guillot,Philippe Connes | | Diabetes Care. 2018; 41(12): 2595 | | [Pubmed] | [DOI] | | | 229 |
Importance and Potential of Dentists in Identifying Patients at High Risk of Diabetes |
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| Siddardha G. Chandrupatla,Ranadheer Ramachandra,Satyanarayana Dantala,Krishnappa Pushpanjali,Mary Tavares | | Current Diabetes Reviews. 2018; 15(1): 67 | | [Pubmed] | [DOI] | | | 230 |
Circulating matrix modulators (MMP-9 and TIMP-1) and their association with severity of diabetic retinopathy |
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| Kuppuswami Jayashree,Md. Yasir,Gandhipuram Periyasamy Senthilkumar,K Ramesh Babu,Vadivelan Mehalingam,Palani Selvam Mohanraj | | Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2018; | | [Pubmed] | [DOI] | | | 231 |
Prevention of Vascular Complications in Diabetes Mellitus Patients: Focus on the Arterial Wall |
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| Mojca Lunder,Miodrag Janic,Mišo Šabovic | | Current Vascular Pharmacology. 2018; 17(1): 6 | | [Pubmed] | [DOI] | | | 232 |
A new indanedione derivative alleviates symptoms of diabetes by modulating RAGE-NF-kappaB pathway in db/db mice |
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| Gulnaz Khan,Meha Fatima Aftab,Bilquees Bano,Khalid Mohammed Khan,Munazza Murtaza,Sonia Siddiqui,M.Hafizur Rehman,Rizwana Sanaullah Waraich | | Biochemical and Biophysical Research Communications. 2018; | | [Pubmed] | [DOI] | | | 233 |
The Big Entity of New RNA World: Long Non-Coding RNAs in Microvascular Complications of Diabetes |
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| Satish K. Raut,Madhu Khullar | | Frontiers in Endocrinology. 2018; 9 | | [Pubmed] | [DOI] | | | 234 |
Synthesis of newly functionalized 1,4-naphthoquinone derivatives and their effects on wound healing in alloxan-induced diabetic mice |
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| Silvia Helena Cardoso,Cleidijane Rodrigues de Oliveira,Ari Souza Guimarães,Jadiely Nascimento,Julianderson de Oliveira dos Santos Carmo,Jamylle Nunes de Souza Ferro,Ana Carolina de Carvalho Correia,Emiliano Barreto | | Chemico-Biological Interactions. 2018; 291: 55 | | [Pubmed] | [DOI] | | | 235 |
Metabolic Parameters, Weight Loss, and Comorbidities 4 Years After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy |
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| Corey J. Lager,Nazanene H. Esfandiari,Yingying Luo,Angela R. Subauste,Andrew T. Kraftson,Morton B. Brown,Oliver A. Varban,Rasimcan Meral,Ruth B. Cassidy,Catherine K. Nay,Amy L. Lockwood,Darlene Bellers,Colleen M. Buda,Elif A. Oral | | Obesity Surgery. 2018; | | [Pubmed] | [DOI] | | | 236 |
There is a positive association between vitamin B12 deficiency and serum total cholesterol in Iranian type 2 diabetic patients on Metformin |
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| Mitra Niafar,Golnaz Samadi,Naser Aghamohammadzadeh,Farzad Najafipour,Zeinab Nikniaz | | Nutrition Clinique et Métabolisme. 2018; | | [Pubmed] | [DOI] | | | 237 |
Effects of High Glucose on the Expression of LAMA1 and Biological Behavior of Choroid Retinal Endothelial Cells |
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| Guangwei Song,Da Lin,Licheng Bao,Qi Jiang,Yinan Zhang,Haihua Zheng,Qianying Gao | | Journal of Diabetes Research. 2018; 2018: 1 | | [Pubmed] | [DOI] | | | 238 |
Assessment of blood glucose variability by continuous monitoring as a therapy guide for patients with diabetic nephropathy on hemodialysis |
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| Ayman Abd-Elrahman Mohamed Nsr-Allah,Mohamed Kamar,Ahmed Sharawy,Nermin Raafat | | The Egyptian Journal of Internal Medicine. 2018; 30(4): 276 | | [Pubmed] | [DOI] | | | 239 |
ACE2 polymorphisms associated with cardiovascular risk in Uygurs with type 2 diabetes mellitus |
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| Cheng Liu,Yanfang Li,Tianwang Guan,Yanxian Lai,Yan Shen,Abudurexiti Zeyaweiding,Haiyan Zhao,Fang Li,Tutiguli Maimaiti | | Cardiovascular Diabetology. 2018; 17(1) | | [Pubmed] | [DOI] | | | 240 |
BMP9 (Bone Morphogenetic Protein-9)/Alk1 (Activin-Like Kinase Receptor Type I) Signaling Prevents Hyperglycemia-Induced Vascular Permeability |
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| Naoufal Akla,Claire Viallard,Natalija Popovic,Cindy Lora Gil,Przemyslaw Sapieha,Bruno Larrivée | | Arteriosclerosis, Thrombosis, and Vascular Biology. 2018; 38(8): 1821 | | [Pubmed] | [DOI] | | | 241 |
Toll-Like Receptor 4 and Heat-Shock Protein 70: Is it a New Target Pathway for Diabetic Vasculopathies? |
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| Amanda Almeida de Oliveira,R. Clinton Webb,Kenia Pedrosa Nunes | | Current Drug Targets. 2018; 20(1): 51 | | [Pubmed] | [DOI] | | | 242 |
The impact of diabetes on treatment in general dental practice |
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| Vinson Yeung,Joht Chandan | | Dental Update. 2018; 45(2): 120 | | [Pubmed] | [DOI] | | | 243 |
Chemotherapeutic-Induced Cardiovascular Dysfunction: Physiological Effects, Early Detection—The Role of Telomerase to Counteract Mitochondrial Defects and Oxidative Stress |
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| Nabeel Quryshi,Laura Norwood Toro,Karima Ait-Aissa,Amanda Kong,Andreas Beyer | | International Journal of Molecular Sciences. 2018; 19(3): 797 | | [Pubmed] | [DOI] | | | 244 |
Endothelin-1 Regulation Is Entangled in a Complex Web of Epigenetic Mechanisms in Diabetes |
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| S. BISWAS,B. FENG,A. THOMAS,S. CHEN,E. AREF-ESHGHI,B. SADIKOVIC,S. CHAKRABARTI | | Physiological Research. 2018; : S115 | | [Pubmed] | [DOI] | | | 245 |
Diabetic retinopathy awareness and associations with multiple comorbidities: Insights from DIAMOND Study |
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| Kiran Shah,Alka Gandhi,Sundaram Natarajan | | Indian Journal of Endocrinology and Metabolism. 2018; 22(1): 30 | | [Pubmed] | [DOI] | | | 246 |
Protective Effect of Inulin and the Integrity of the Microvasculature in Diabetes Mellitus |
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| Wassef Girgiss Nicola,Mina Wassef Girgiss,Aly Mohamed Ezz El-Arab,Dawoud Fakhry Habib,Mohamed qElsayed Elnemr,Nadia Mohamed Ahmed,Eman Refaat Youness | | Biomedical and Pharmacology Journal. 2018; 11(2): 807 | | [Pubmed] | [DOI] | | | 247 |
The effect of change in fasting glucose on the risk of myocardial infarction, stroke, and all-cause mortality: a nationwide cohort study |
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| Gyeongsil Lee,Sung Min Kim,Seulggie Choi,Kyuwoong Kim,Su-Min Jeong,Joung Sik Son,Jae-Moon Yun,Sang Min Park | | Cardiovascular Diabetology. 2018; 17(1) | | [Pubmed] | [DOI] | | | 248 |
GLP-1 Receptor Agonists and Cardiovascular Disease in Patients with Type 2 Diabetes |
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| María Isabel del Olmo-Garcia,Juan Francisco Merino-Torres | | Journal of Diabetes Research. 2018; 2018: 1 | | [Pubmed] | [DOI] | | | 249 |
Beetle (Ulomoides dermestoides) fat improves diabetes: effect on liver and pancreatic architecture and on PPAR? expression |
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| E.I. Jasso-Villagomez,M. Garcia-Lorenzana,J.C. Almanza-Perez,M.A. Fortis-Barrera,G. Blancas-Flores,R. Roman-Ramos,L.A. Prado-Barragan,F.J. Alarcon-Aguilar | | Brazilian Journal of Medical and Biological Research. 2018; 51(6) | | [Pubmed] | [DOI] | | | 250 |
Altered expression of WFS1 and NOTCH2 genes associated with diabetic nephropathy in T2DM patients |
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| Sahar A. Sharaf,Nagwa A. Kantoush,Dina F. Ayoub,Alshaymaa A. Ibrahim,Amaal A. Abdelaal,Rokaya Abdel Aziz,Mahmoud M. ElHefnawi,Amira N. Ahmed | | Diabetes Research and Clinical Practice. 2018; 140: 304 | | [Pubmed] | [DOI] | | | 251 |
STAT3 and Nrf2 pathways modulate the protective effect of verapamil on lung injury of diabetic rats |
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| Mervat Z. Mohamed,Heba M. Hafez,Hanaa H. Mohamed,Nagwa M. Zenhom | | Endocrine Regulations. 2018; 52(4): 192 | | [Pubmed] | [DOI] | | | 252 |
Patient reported experience of blood glucose management when undergoing hyperbaric oxygen treatment |
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| Carol Baines,Geraldine O’Rourke,Charne Miller,Karen Ford,William McGuiness | | Collegian. 2018; | | [Pubmed] | [DOI] | | | 253 |
A review of the anti-inflammatory properties of antidiabetic agents providing protective effects against vascular complications in diabetes |
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| Habib Yaribeygi,Stephen L. Atkin,Matteo Pirro,Amirhossein Sahebkar | | Journal of Cellular Physiology. 2018; | | [Pubmed] | [DOI] | | | 254 |
Glycaemic indices and haemoglobin A1c as predictors for non-healing ulcers |
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| Kevin J. Moore,Erin C. Dunn,Erin N. Marcus,Tulay Koru-Sengul | | Journal of Wound Care. 2018; 27(Sup4): S6 | | [Pubmed] | [DOI] | | | 255 |
Danhong Huayu Koufuye Prevents Diabetic Retinopathy in Streptozotocin-Induced Diabetic Rats via Antioxidation and Anti-Inflammation |
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| Wenpei Chen,Xiaolan Yao,Chenghao Zhou,Ziyang Zhang,Gang Gui,Baoqin Lin | | Mediators of Inflammation. 2017; 2017: 1 | | [Pubmed] | [DOI] | | | 256 |
Mitochondrial miRNAs in diabetes: just the tip of the iceberg |
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| Rohini Baradan,John M. Hollander,Samarjit Das | | Canadian Journal of Physiology and Pharmacology. 2017; : 1 | | [Pubmed] | [DOI] | | | 257 |
Pancreatic Elastography From Acoustic Radiation Force Impulse Imaging for Evaluation of Diabetic Microangiopathy |
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| Yu He,Hui Wang,Xiao Ping Li,Juan-Juan Zheng,Chun-Xiang Jin | | American Journal of Roentgenology. 2017; : 1 | | [Pubmed] | [DOI] | | | 258 |
Targeting Obesity and Diabetes to Treat Heart Failure with Preserved Ejection Fraction |
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| Raffaele Altara,Mauro Giordano,Einar S. Nordén,Alessandro Cataliotti,Mazen Kurdi,Saeed N. Bajestani,George W. Booz | | Frontiers in Endocrinology. 2017; 8 | | [Pubmed] | [DOI] | | | 259 |
Expression of JAZF1, ABCC8, KCNJ11and Notch2 genes and vitamin D receptor polymorphisms in type 2 diabetes, and their association with microvascular complications |
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| Maha A. Rasheed,Nagwa Kantoush,Nagwa Abd El-Ghaffar,Hebatallah Farouk,Solaf Kamel,Alshaymaa Ahmed Ibrahim,Aliaa Shalaby,Eman Mahmoud,Hala M. Raslan,Omneya M. Saleh | | Therapeutic Advances in Endocrinology and Metabolism. 2017; 8(6): 97 | | [Pubmed] | [DOI] | | | 260 |
Long-term efficacy and safety of sodium-glucose cotransporter-2 inhibitors as add-on to metformin treatment in the management of type 2 diabetes mellitus |
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| Jian Li,Yanping Gong,Chunlin Li,Yanhui Lu,Yu Liu,Yinghong Shao | | Medicine. 2017; 96(27): e7201 | | [Pubmed] | [DOI] | | | 261 |
MicroRNA and Diabetic Complications- a clinical perspective |
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| Baoqi Fan,Andrea On Yan Luk,Juliana C.N. Chan,Ronald Ching Wan Ma | | Antioxidants & Redox Signaling. 2017; | | [Pubmed] | [DOI] | | | 262 |
Prevalence of Osteoporosis in Type 2 Diabetes Mellitus Patients Using Dual Energy X-Ray Absorptiometry (DEXA) Scan |
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| Shivank Prakash,Ravi. S. Jatti,Shridhar C. Ghagane,S.M. Jali,M.V. Jali | | International Journal of Osteoporosis and Metabolic Disorders. 2017; 10(2): 10 | | [Pubmed] | [DOI] | | | 263 |
Renoprotective Effects of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin: A Review in Type 2 Diabetes |
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| Cristina Mega,Edite Teixeira-de-Lemos,Rosa Fernandes,Flávio Reis | | Journal of Diabetes Research. 2017; 2017: 1 | | [Pubmed] | [DOI] | | | 264 |
Novel insights into DNA methylation and its critical implications in diabetic vascular complications |
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| Jia Zheng,Jing Cheng,Qian Zhang,Xinhua Xiao | | Bioscience Reports. 2017; 37(2) | | [Pubmed] | [DOI] | | | 265 |
Restoration of Impaired Metabolic Energy Balance (ATP Pool) and Tube Formation Potential of Endothelial Cells under “high glucose”, Diabetic Conditions by the Bioinorganic Polymer Polyphosphate |
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| Xiaohong Wang,Maximilian Ackermann,Meik Neufurth,Shunfeng Wang,Qiang Li,Qingling Feng,Heinz Schröder,Werner Müller | | Polymers. 2017; 9(11): 575 | | [Pubmed] | [DOI] | | | 266 |
Serum vaspin concentration in elderly patients with type 2 diabetes mellitus and macrovascular complications |
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| Wei Yang,Yun Li,Tian Tian,Li Wang,Pearl Lee,Qi Hua | | BMC Endocrine Disorders. 2017; 17(1) | | [Pubmed] | [DOI] | | | 267 |
Epigenetics in diabetic nephropathy, immunity and metabolism |
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| Samuel T. Keating,Janna A. van Diepen,Niels P. Riksen,Assam El-Osta | | Diabetologia. 2017; | | [Pubmed] | [DOI] | | | 268 |
Role of protein carbonylation in diabetes |
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| Markus Hecker,Andreas H. Wagner | | Journal of Inherited Metabolic Disease. 2017; | | [Pubmed] | [DOI] | | | 269 |
Analysis of inflammatory cytokine and TLR expression levels in Type 2 Diabetes with complications |
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| Saket Gupta,Ashwini Maratha,Jakub Siednienko,Anandan Natarajan,Thusitha Gajanayake,Shu Hoashi,Sinéad Miggin | | Scientific Reports. 2017; 7(1) | | [Pubmed] | [DOI] | | | 270 |
Incidence of complications in young-onset diabetes: Comparing type 2 with type 1 (the young diab study) |
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| Anandakumar Amutha,Ranjit Mohan Anjana,Ulagamathesan Venkatesan,Harish Ranjani,Ranjit Unnikrishnan,K.M. Venkat Narayan,Viswanathan Mohan,Mohammed K. Ali | | Diabetes Research and Clinical Practice. 2017; 123: 1 | | [Pubmed] | [DOI] | | | 271 |
O-GlcNAc modification of Sp1 mediates hyperglycaemia-induced ICAM-1 up-regulation in endothelial cells |
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| Yuan Zhang,Yuan Qu,Tian Niu,Haiyan Wang,Kun Liu | | Biochemical and Biophysical Research Communications. 2017; 484(1): 79 | | [Pubmed] | [DOI] | | | 272 |
Dynamics of Diabetes and Obesity: Epidemiological Perspective |
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| Annette Boles,Ramesh Kandimalla,P. Hemachandra Reddy | | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2017; | | [Pubmed] | [DOI] | | | 273 |
Reduced serum milk fat globule-epidermal growth factor 8 (MFG-E8) concentrations are associated with an increased risk of microvascular complications in patients with type 2 diabetes |
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| Guohua Sun,Juxiang Liu,Guanghao Xia,Lijuan Zhang,Yonghong Li,Zubang Zhou,Yaya LV,Suhong Wei,Jing Liu,Jinxing Quan | | Clinica Chimica Acta. 2017; 466: 201 | | [Pubmed] | [DOI] | | | 274 |
Significance of cardiac and iron profile alteration in diabetic patients |
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| Nabil A. Hasona | | Comparative Clinical Pathology. 2017; | | [Pubmed] | [DOI] | | | 275 |
Effect of Pseudocereal-Based Breakfast Meals on the First and Second Meal Glucose Tolerance in Healthy and Diabetic Subjects |
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| Shreef G.N. Gabrial,Marie-Christine R. Shakib,Gamal N. Gabrial | | Open Access Macedonian Journal of Medical Sciences. 2016; 4(4): 565 | | [Pubmed] | [DOI] | |
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