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Year : 2016  |  Volume : 20  |  Issue : 5  |  Page : 679-683

Demographic and clinical characteristics of the children with aminoacidopathy in Isfahan Province, Central Iran in 2007-2015

1 Department of Pediatric Endocrinology and Metabolism, Ilam University of Medical Sciences, Ilam; Endocrine and Metabolism Research Center, University of Medical Sciences, Isfahan, Iran
2 Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Pediatric Neurology, University of Medical Sciences, Isfahan, Iran
4 Internal and Surgical Nursing, Ilam University of Medical Sciences, Ilam, Iran
5 Medical Student, University of New South Wales, Sydney NSW 2052, Australia

Correspondence Address:
Mahin Hashemipour
Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2230-8210.190556

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Context: Aminoacidopathies refer to defects in protein synthesis pathways which result in a range of biochemical disorders and clinical presentations. The enzyme defects in intermediate metabolic pathways lead to accumulation of one or more amino acids or metabolites. Despite higher prevalence rates, screening infants for inherited metabolic disorders is not run in many Middle East countries. Aim: This research is part of a larger study of inherited metabolic disorders to characterize and measure the prevalence of aminoacidopathies. Settings and Design: Cross-sectional study in the population aged 0-17 years old in Isfahan province of Iran, 2007-2015. Subjects and Methods: Demographic characteristics, history of disease, development of clinical condition and socioeconomic status were obtained from interviews as well as patient records of pediatric tertiary referral hospitals and metabolic disorders centers. Statistical Analysis Used: SPSS qualitative and quantitative analysis. Results: The incidence rate of aminoacidopathies was derived to be 9/100,000 live births. The frequency of consanguineous marriages in this group of the patients was 89.2%. Of the patients with aminoacidopathies, 76.6% required hospitalization with tyrosinemia having the highest rate overall (>10 times). The most prevalent symptoms in this group of patients were developmental disorders and convulsions while half presented with growth disorders during follow-up. Of the 35.5% patients, who died at various ages, one-third was in the maple syrup urine disease subgroup. Conclusion: Although metabolic disorders are identified as rare diseases, they are more prevalent in the studied population of Isfahan.

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