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Year : 2017  |  Volume : 21  |  Issue : 6  |  Page : 848-853

Role of parathyroid hormone in determination of fat mass in patients with Vitamin D deficiency

1 Department of Endocrinology, ILSI, New Delhi, India
2 Departmemt of Endocrinology, Command Hospital (Southern Command), Pune, Maharashtra, India
3 Department of Pathology, Deenanath Mangeshkar Hospital and Research Center, Pune, Maharashtra, India
4 Department of Endocrinology, Thyroid Research Centre, Institute of Nuclear Medicine and Allied Sciences, New Delhi, India
5 Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Raman K Marwaha
ILSI, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijem.IJEM_42_17

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Background: Obesity has become a global epidemic and it is rising is Asia. Vitamin D deficiency (VDD) is widely prevalent in the Indian subcontinent. Studies have linked VDD to obesity and shown correlation between parathyroid hormone (PTH), 25-hydroxy Vitamin D (25(OH)D), and fat mass (FM). However, studies on the role of PTH among subjects with VDD are lacking. Objective: The objective of this study is to study the role of PTH in the determination of FM in participants with VDD. Subjects: Five hundred and fifty-one adults (m:247, f:304) were included in this study. Materials and Methods: Total and regional (trunk, arm, and leg) FM was assessed by dual X-ray absorptometry. Biochemical and hormonal parameters such as calcium, phosphorus, alkaline phosphatase, ionic calcium, 25(OH)D, and PTH were also analyzed. Results: The mean age of the study population was 58.8 ± 15.8 years (Male: [63.3 ± 13.1], Female: [55.2 ± 16.9]). FM and body mass index were significantly lower in females with higher levels of serum 25(OH)D. Total FM was negatively correlated with serum 25(OH)D (r = −0.363, P < 0.0001) and positively correlated with serum PTH (r: 0.262, P < 0.0001) in females only. Females with VDD and secondary hyperparathyroidism had higher FM than those with normal PTH. Conclusions: Females with VDD had higher total and regional FM. However, this correlation was evident only in those with high serum PTH levels, suggesting a potential role of PTH in the accumulation of FM.

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