Indian Journal of Endocrinology and Metabolism

MINI REVIEW
Year
: 2012  |  Volume : 16  |  Issue : 8  |  Page : 272--274

Multiple endocrine neoplasia type 1


RV Thakker 
 Nuffield Department of Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Headington, Oxford, OX3 7LJ, United Kingdom

Correspondence Address:
R V Thakker
Nuffield Department of Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism,University of Oxford, Headington, Oxford, OX3 7LJ
United Kingdom

Multiple endocrine neoplasia type 1 (MEN1) is characterized by the occurrence of parathyroid, pancreatic islet and anterior pituitary tumors. Some patients may also develop carcinoid tumors, adrenocortical tumors, facial angiofibromas, collagenomas, and lipomas. MEN1 is an autosomal-dominant disorder, due to mutations in the tumor suppressor gene MEN1, which encodes a 610 amino acid protein, menin. Thus, the finding of MEN1 in a patient has important implications for family members because first-degree relatives have a 50% risk of developing the disease and can often be identified by MEN1 mutational analysis. Patients with MEN1 have a decreased life-expectancy and the outcomes of current treatments, which are generally similar to that for the respective tumors occurring in non-MEN1 patients, are not as successful because of multiple tumors, which may be larger, more aggressive, and resistant to treatment, and the concurrence of metastases. The prognosis for MEN1 patients might be improved by pre-symptomatic tumor detection and undertaking treatment specific for MEN1-tumors. Thus, it is recommended that MEN1 patients and their families should be cared for by multi-disciplinary teams comprising relevant specialists with experience in the diagnosis and treatment of patients with endocrine tumors.


How to cite this article:
Thakker R V. Multiple endocrine neoplasia type 1.Indian J Endocr Metab 2012;16:272-274


How to cite this URL:
Thakker R V. Multiple endocrine neoplasia type 1. Indian J Endocr Metab [serial online] 2012 [cited 2021 Sep 17 ];16:272-274
Available from: https://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=8;spage=272;epage=274;aulast=Thakker;type=0