Indian Journal of Endocrinology and Metabolism

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 18  |  Issue : 2  |  Page : 221--225

Correlation between serum adiponectin and clinical characteristics, biochemical parameters in Indian women with polycystic ovary syndrome


Sunita J Ramanand1, Jaiprakash B Ramanand2, Balasaheb B Ghongane1, Milind H Patwardhan3, Varsha M Patwardhan3, Ravi Ghanghas1, Nimish R Halasawadekar1, Praveenkumar Patil1 
1 Department of Pharmacology, Govt. Medical College, Miraj, Maharashtra, India
2 Department of Pharmacology, R.C.S.M. Government Medical College, Kolhapur, Maharashtra, India
3 Patwardhan Endocrinology Hospital and Research Centre, Miraj, Maharashtra, India

Correspondence Address:
Sunita J Ramanand
Department of Pharmacology, Government Medical College, Miraj - 416 410, Maharashtra
India

Background: Polycystic ovary syndrome (PCOS) is a common disorder. PCOS women are at a high risk for insulin resistance and metabolic syndrome (MS). Adiponectin is positively related to insulin sensitivity. It has a preventive role in atherogenesis and MS. The present work was conducted to study the correlation between serum adiponectin levels and clinical characteristics and biochemical parameters in PCOS patients. Materials and Methods: A prospective study in 49 newly diagnosed (as per Rotterdam criteria) Indian PCOS women was conducted. PCOS women were clinically examined and investigated for biochemical parameters. Results : The mean serum adiponectin was 12 ± 9.4 μg/mL (range 0.47-45). Hypoadiponectinemia (serum adiponectin <4 μg/mL) was present in 22% patients. Age and adiponectin correlated significantly and inversely (r = −0.42, P = 0.027). Overweight/obese patients had lower mean adiponectin levels than normal weight (11.62 ± 9.5 vs 13.58 ± 9.5, P = 0.56). It was significantly lower in patients with acanthosis nigricans (AN) as compared with those without AN (8.4 ± 5.9 vs 15 ± 11, P = 0.038). Hirsute patients showed lower mean adiponectin levels than nonhirsute (10 ± 7.3 vs 13 ± 10, P = 0.57). A positive, insignificant correlation was observed between serum adiponectin and cholesterol, low-density lipoprotein, follicle stimulating hormone (FSH), thyroid stimulating hormone, levels. A negative insignificant correlation existed between serum adiponectin and luteinizing hormone (LH), LH: FSH ratio, prolactin, dehydroepiandrosterone, testosterone, triglyceride, high-density lipoprotein, fasting blood glucose, fasting insulin, and Homeostasis Model Assessment. Conclusion: Hypoadiponectinemia is present in one-fifth of women with PCOS. Adiponectin levels decrease as age advances. Low levels of adiponectin possibly contributes to the development of dermal manifestation (AN) of insulin resistance.


How to cite this article:
Ramanand SJ, Ramanand JB, Ghongane BB, Patwardhan MH, Patwardhan VM, Ghanghas R, Halasawadekar NR, Patil P. Correlation between serum adiponectin and clinical characteristics, biochemical parameters in Indian women with polycystic ovary syndrome.Indian J Endocr Metab 2014;18:221-225


How to cite this URL:
Ramanand SJ, Ramanand JB, Ghongane BB, Patwardhan MH, Patwardhan VM, Ghanghas R, Halasawadekar NR, Patil P. Correlation between serum adiponectin and clinical characteristics, biochemical parameters in Indian women with polycystic ovary syndrome. Indian J Endocr Metab [serial online] 2014 [cited 2020 Oct 20 ];18:221-225
Available from: https://www.ijem.in/article.asp?issn=2230-8210;year=2014;volume=18;issue=2;spage=221;epage=225;aulast=Ramanand;type=0