Indian Journal of Endocrinology and Metabolism

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 18  |  Issue : 6  |  Page : 826--830

Expression of p53, Ki67, epidermal growth factor receptor, transforming growth-factorα, and p21 in primary and secondary hyperparathyroidism


Saime Paydas1, Arbil Acikalim2, Bulent Kaya1, Bermal Hasbay Bicer2, Mehmet Ulker1, Orhan Demircan1, Aysun Uguz2, Mustafa Balal1, Gurhan Sakman1, Yasar Sertdemir3, Refika Karaer1, Eda Altun1 
1 Department of Nephrology, Faculty of Medicine, Cukurova University, Adana, Turkey
2 Department of Pathology and General Surgery, Faculty of Medicine, Cukurova University, Adana, Turkey
3 Department of Biostatistics, Faculty of Medicine, Cukurova University, Adana, Turkey

Correspondence Address:
Prof. Saime Paydas
Department of Nephrology, Faculty of Medicine, Cukurova University, 01330, Adana
Turkey

Background: Secondary hyperparathyroidism (SH) is major problem in chronic renal failure. There are studies to examine proliferation and apoptosis associated biomarkers expressions in parathyroid lesions to reveal specific features. In this study, we evaluated the expression of some growth factors and their receptors in parathyroid gland of patients with SH or primary hyperparathyroidism (PH). Materials and Methods: A total of 49 patients had been operated for PH and 26 for SH. Parathyroid tissue samples were evaluated histopathologically and immunohistochemically using antibodies to human p53, Kİ-67, anti-human p21, antitransforming growth factor (TGF) α, CPP32 (caspase 3), and epidermal growth factor receptor (EGFR). Results: Adenoma was higher in PH compared with SH as 48/49 and 3/26, respectively (P = 0.000). Parathyroid hyperplasia was found in 23/26 patients with SH and 1/49 patient with PH. In parathyroid tissue there were no difference between PH and SH for p53, Ki-67, caspase, EGFR expressions; while there were significantly difference for TGFα (P = 0.047) and borderline significant difference for p21 (P = 0.06) expressions. Conclusion: Adenoma was priority present in PH patients, hyperplasia was present in SH. There were no differences between primary and SH or adenoma and hyperplasia for expressions of cycline-dependent kinase inhibitor p21, p53, EGFR, Ki67, caspase; while TGFα expression was found to be different.


How to cite this article:
Paydas S, Acikalim A, Kaya B, Bicer BH, Ulker M, Demircan O, Uguz A, Balal M, Sakman G, Sertdemir Y, Karaer R, Altun E. Expression of p53, Ki67, epidermal growth factor receptor, transforming growth-factorα, and p21 in primary and secondary hyperparathyroidism.Indian J Endocr Metab 2014;18:826-830


How to cite this URL:
Paydas S, Acikalim A, Kaya B, Bicer BH, Ulker M, Demircan O, Uguz A, Balal M, Sakman G, Sertdemir Y, Karaer R, Altun E. Expression of p53, Ki67, epidermal growth factor receptor, transforming growth-factorα, and p21 in primary and secondary hyperparathyroidism. Indian J Endocr Metab [serial online] 2014 [cited 2021 Apr 17 ];18:826-830
Available from: https://www.ijem.in/article.asp?issn=2230-8210;year=2014;volume=18;issue=6;spage=826;epage=830;aulast=Paydas;type=0