Indian Journal of Endocrinology and Metabolism

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 18  |  Issue : 6  |  Page : 846--849

Treatment of diabetes mellitus-associated neuropathy with vitamin E and Eve primrose


Anthonia Okeoghene Ogbera1, Emmanuel Ezeobi1, Chioma Unachukwu2, Olajumoke Oshinaike1 
1 Department of Medicine, Lagos State University Teaching Hospital, Ikeja, Lagos State, Nigeria
2 Department of Medicine, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria

Correspondence Address:
Assoc. Prof. Anthonia Okeoghene Ogbera
Department of Medicine, Lagos State University College of Medicine, Ikeja, Lagos
Nigeria

Background: The aim of this report was to assess the efficacy and safety of a combination of vitamin E, an antioxidant, and Eve Primrose in the management of painful diabetes mellitus (DM) neuropathy. Materials and Methods: This was an interventional study that evaluated the efficacy and safety of a combination of vitamin E and Eve Primrose in the management of DM neuropathy. The study was conducted at the Diabetic Centre of the Lagos State University Teaching Hospital, Ikeja. Eighty individuals with type 2 DM who had painful neuropathy were recruited for this study, which took place for a duration of 1 year. The study subjects underwent clinical and biochemical assessment at baseline and were given vitamin E in a dose of 400 mg in combination with Eve Primrose in doses ranging 500-1000 mg/day. They were afterward assessed for relief of symptoms and possible untoward effects after 2 weeks and, thereafter, monthly for 3 months. The main outcome measure was amelioration of symptoms of neuropathy . Results: The mean age and age range of the study subjects were 58.2 years and 37-70 years, respectively. A total of 70 patients (88%) of the study population reported relief from neuropathic pains. Clinical parameters were comparable between the responders and non-responders. One characteristic feature of the non-responders was that they all had vibration perception threshold of ≥25 mV, which was indicative of severe neuropathy. Conclusion: The combination of vitamin E and Eve Primrose is beneficial in the management of mild to moderate diabetic neuropathy.


How to cite this article:
Ogbera AO, Ezeobi E, Unachukwu C, Oshinaike O. Treatment of diabetes mellitus-associated neuropathy with vitamin E and Eve primrose.Indian J Endocr Metab 2014;18:846-849


How to cite this URL:
Ogbera AO, Ezeobi E, Unachukwu C, Oshinaike O. Treatment of diabetes mellitus-associated neuropathy with vitamin E and Eve primrose. Indian J Endocr Metab [serial online] 2014 [cited 2021 Jan 28 ];18:846-849
Available from: https://www.ijem.in/article.asp?issn=2230-8210;year=2014;volume=18;issue=6;spage=846;epage=849;aulast=Ogbera;type=0