Indian Journal of Endocrinology and Metabolism

BRIEF COMMUNICATION
Year
: 2015  |  Volume : 19  |  Issue : 7  |  Page : 71--73

Basal insulin analogues in the treatment of diabetes mellitus: What progress have we made?


Sanjay Kalra 
 Department of Endocrinology, Bharti Hospital and B. R. I. D. E., Karnal, Haryana, India

Correspondence Address:
Sanjay Kalra
Bharti Hospital and B. R. I. D. E., Karnal - 132 001, Haryana
India

Over the past few decades, continuous progress has been made in the development of insulin therapy. Basal insulins were developed around 60 years ago. However, existing basal insulins were found to have limitations. An ideal basal insulin should have the following properties viz. longer duration of action, a flat time-action profile, low day-to-day glycaemic variability, and the potential for flexible dosing. Basal insulins have advanced over the years, from lectin and neutral protamine Hagedorn to the currently available insulin degludec. Currently, the focus is on developing a basal insulin that can give coverage for the entire day, with lesser variability and flexible administration. Insulin degludec has been a significant leap in that direction. In addition, U300 insulin glargine and pegylated lispro represent further developments in basal insulin pharmacotherapeutics.


How to cite this article:
Kalra S. Basal insulin analogues in the treatment of diabetes mellitus: What progress have we made?.Indian J Endocr Metab 2015;19:71-73


How to cite this URL:
Kalra S. Basal insulin analogues in the treatment of diabetes mellitus: What progress have we made?. Indian J Endocr Metab [serial online] 2015 [cited 2021 Apr 13 ];19:71-73
Available from: https://www.ijem.in/article.asp?issn=2230-8210;year=2015;volume=19;issue=7;spage=71;epage=73;aulast=Kalra;type=0