Indian Journal of Endocrinology and Metabolism

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 20  |  Issue : 1  |  Page : 108--113

Effect of hypothyroidism on female reproductive hormones


Sanjay Saran1, Bharti Sona Gupta2, Rajeev Philip3, Kumar Sanjeev Singh4, Sureshrao Anoop Bende5, Puspalata Agroiya6, Pankaj Agrawal7 
1 Department of Endocrinology, LLRM Medical College, Meerut, Uttar Pradesh, India
2 Department of Biochemistry, Subharti Medical College, Meerut, Uttar Pradesh, India
3 Department of Endocrinology, Pushpagiri Medical College, Thiruvalla, Kerala, India
4 Department of Medicine, King George Medical College, Lucknow, Uttar Pradesh, India
5 Department of Medicine, LLRM Medical College, Meerut, Uttar Pradesh, India
6 Department of Ophthalmology, LLRM Medical College, Meerut, Uttar Pradesh, India
7 Hormone Care and Research Centre, Ghaziabad, Uttar Pradesh, India

Correspondence Address:
Sanjay Saran
3B Dwarika Towers Opposite, LLRM Medical College, Meerut - 250 004, Uttar Pradesh
India

Objective: Objective was to evaluate reproductive hormones levels in hypothyroid women and impact of treatment on their levels. Materials and Methods: A total of 59 women with untreated primary hypothyroidism were included in this prospective study. Venous blood was taken at baseline and after euthyroidism was achieved for measuring serum free thyroxine, free triiodothyronine (FT3), thyroid stimulating hormone (TSH), prolactin (PRL), follicular stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), testosterone (T), and thyroid peroxidase antibody. Thirty-nine healthy women with regular menstrual cycles without any hormonal disturbances served as controls. The statistical analysis was performed using the Statistical Package for the Social Sciences Version 20 ([SPSS] IBM Corporation, Armonk, NY, USA). P < 0.05 was considered statistically significant. Results: On an average at diagnosis cases have more serum TSH (mean[M] = 77.85; standard error [SE] = 11.72), PRL (M = 39.65; SE = 4.13) and less serum E2(M = 50.00; SE = 2.25) and T (M = 35.40; SE = 2.31) than after achieving euthyroidism (M = 1.74; SE = 0.73), (M = 16.04; SE = 0.84), (M = 76.25; SE = 2.60), and (M = 40.29; SE = 2.27), respectively. This difference was statistically significant t(58) = 6.48, P <0.05; t(58) = 6.49, P < 0.05; t(58) = 12.47; P <0.05; and t(58) = 2.04, P <0.05; respectively. Although average serum FSH(M = 12.14; SE = 0.40) and LH (M = 5.89; SE = 0.27) were lower in cases at diagnosis than after achieving euthyroidism (M = 12.70; SE = 0.40),(M = 6.22; SE = 0.25), respectively, but these differences were statistically insignificant t(58) = 1.61, P = 0.11; t(58) = 1.11, P = 0.27, respectively. Conclusion: The study has demonstrated low E2 and T levels in hypothyroid women which were increased after achieving euthyroidism. Although average serum FSH and LH were increased in hypothyroid women after achieving euthyroidism but this difference was statistically insignificant.


How to cite this article:
Saran S, Gupta BS, Philip R, Singh KS, Bende SA, Agroiya P, Agrawal P. Effect of hypothyroidism on female reproductive hormones.Indian J Endocr Metab 2016;20:108-113


How to cite this URL:
Saran S, Gupta BS, Philip R, Singh KS, Bende SA, Agroiya P, Agrawal P. Effect of hypothyroidism on female reproductive hormones. Indian J Endocr Metab [serial online] 2016 [cited 2021 Apr 17 ];20:108-113
Available from: https://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=1;spage=108;epage=113;aulast=Saran;type=0