Indian Journal of Endocrinology and Metabolism

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 20  |  Issue : 5  |  Page : 595--599

Long-term efficacy of liraglutide in Indian patients with Type 2 diabetes in a real-world setting


Parjeet Kaur, Shama Mahendru, Ambrish Mithal 
 Division of Endocrinology and Diabetes, Medanta - The Medicity, Gurgaon, Haryana, India

Correspondence Address:
Parjeet Kaur
Division of Endocrinology and Diabetes, Medanta - The Medicity, Gurgaon, Sector 38, Gurgaon - 122 001, Haryana
India

Background: Long-term efficacy of liraglutide, a glucagon-like peptide-1 analog, on body weight and glycemic control has not been studied in Indian Type 2 diabetes mellitus (T2DM) subjects. Aim: To evaluate the effect of liraglutide on glycemic control and body weight for 1 year in Indian T2DM patients. Methods: Liraglutide was prescribed to 96 obese patients with T2DM and followed up for 1 year. Clinical parameters were measured at baseline and 3, 6, 9, and 12 months. Dosage of liraglutide and other medications was adjusted according to clinical judgment. Results: 1 year data were available for 74 patients. Mean age was 50.9 ± 9.6 years. Mean duration of diabetes was 11.6 ± 6.3 years. Glycosylated hemoglobin (HbA1c) significantly decreased from 8.9 ± 1.3% at baseline to 7.4 ± 1.2% at 1 year. Body weight significantly declined from 98.9 ± 16.0 kg at baseline to 93.8 ± 15.0 kg at 1 year. After an initial decline, subset of patients had an increase in mean HbA1c (n = 30/74) and mean body weight (n = 33/74) after 6 months of liraglutide initiation. Baseline HbA1c and baseline body weight were positively associated with a reduction of HbA1c and body weight at 1 year, respectively. No major side effects occurred. Conclusion: Liraglutide treatment resulted in a significant and sustained reduction in HbA1c and body weight over 1 year in Indian T2DM patients. Magnitude of reduction of HbA1c and body weight at 1 year was positively associated with baseline HbA1c and baseline weight, respectively.


How to cite this article:
Kaur P, Mahendru S, Mithal A. Long-term efficacy of liraglutide in Indian patients with Type 2 diabetes in a real-world setting.Indian J Endocr Metab 2016;20:595-599


How to cite this URL:
Kaur P, Mahendru S, Mithal A. Long-term efficacy of liraglutide in Indian patients with Type 2 diabetes in a real-world setting. Indian J Endocr Metab [serial online] 2016 [cited 2021 Jan 28 ];20:595-599
Available from: https://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=5;spage=595;epage=599;aulast=Kaur;type=0