Indian Journal of Endocrinology and Metabolism

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 21  |  Issue : 6  |  Page : 859--863

Carotid intima-medial thickness and glucose homeostasis in Indian obese children and adolescents


Aashima Dabas1, Thushanth Thomas1, Monita Gahlot2, Nandita Gupta1, K Devasenathipathy3, Rajesh Khadgawat1 
1 Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India
2 Department of Dietetics, All India Institute of Medical Sciences, New Delhi, India
3 Department of Radiology, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Rajesh Khadgawat
Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, Ansari Nagar, New Delhi - 110 029
India

Objective: To evaluate for subclinical atherosclerosis and its risk factors in Indian obese children. Materials and Methods: A cross-sectional, case–control study was conducted to recruit 80 children aged 6–17 years with constitutional obesity as cases and 23 age- and gender-matched controls with normal body mass index (BMI). Anthropometric and clinical evaluation was followed by biochemical analysis and body fat estimation by dual-energy X-ray absorptiometry in cases. Similar evaluation was performed for controls except laboratory parameters. Carotid intima-media thickness (CIMT) was measured with B-mode ultrasonography in both cases and controls to evaluate subclinical atherosclerosis. Results: The mean age of cases was 12.8 ± 3 years, with mean BMI of 29.2 ± 4.8 kg/m2. The mean CIMT was significantly higher in cases than controls (0.54 ± 0.13 vs. 0.42 ± 0.08; P < 0.001 across all ages). CIMT was significantly higher in participants who were hypertensive than nonhypertensive (0.6 ± 0.11 vs. 0.53 ± 0.11 mm; P = 0.04). CIMT showed a positive correlation with BMI (r = 0.23, P = 0.02), percentage body fat and fat mass index (r = 0.28 and 0.3 respectively; P < 0.001), but not with waist: hip ratio. CIMT showed significant positive correlation with blood glucose at 60 min (r = 0.22; P = 0.04), serum insulin at 60 min (r = 0.28; P = 0.01) while negative correlation with whole body insulin sensitivity (r = −0.27; P = 0.01). Conclusion: CIMT correlated significantly to blood pressure, insulin sensitivity, and body fat in Indian obese children.


How to cite this article:
Dabas A, Thomas T, Gahlot M, Gupta N, Devasenathipathy K, Khadgawat R. Carotid intima-medial thickness and glucose homeostasis in Indian obese children and adolescents.Indian J Endocr Metab 2017;21:859-863


How to cite this URL:
Dabas A, Thomas T, Gahlot M, Gupta N, Devasenathipathy K, Khadgawat R. Carotid intima-medial thickness and glucose homeostasis in Indian obese children and adolescents. Indian J Endocr Metab [serial online] 2017 [cited 2021 Sep 22 ];21:859-863
Available from: https://www.ijem.in/article.asp?issn=2230-8210;year=2017;volume=21;issue=6;spage=859;epage=863;aulast=Dabas;type=0