Year : 2018 | Volume
: 22 | Issue : 2 | Page : 200--203
The deletion polymorphism in exon 8 of uncoupling protein 2 is associated with severe obesity in a Saudi Arabian case–control study
Yahia A Kaabi
Department of Medical Laboratory Technology, College of Applied Medical Sciences, Jazan University, Jazan, Kingdom of Saudi Arabia
Context: Obesity is a major health concern in Saudi Arabia. Uncoupling protein 2 (UCP2) seems to play a major role in the regulation of human metabolism; therefore, genetic polymorphisms in the UCP2 gene might contribute to obesity.
Aim: This study aims to establish whether 45-blood pressure (BP) insertion (I)/deletion (D) polymorphisms in UCP2 are associated with moderate and/or severe obesity in a Saudi Arabian population.
Settings and Design: Case–control study design.
Materials and Methods: The study enrolled 151 male and female subjects originating from the eastern province of Saudi Arabia, and assigned each to a “nonobese,” “moderately obese,” or “severely obese” group. Genomic DNA was extracted from all subjects and screened for UCP2 I/D polymorphisms using a standard polymerase chain response protocol.
Statistical Analysis Used: Analysis of variance, Chi-squared tests, and logistic regression analysis.
Results: The frequencies of the UCP2 45-BP I/D genotypes D/D, I/D, and I/I within the analyzed population were 58.3%, 36.4%, and 5.3%, respectively. The D/D genotype was highly prevalent within the severely obese group (82.9%) compared to the nonobese (46.2%) and moderately obese (53.3%) groups. Using a dominance model, the conducted logistic regression analysis showed a strong association between the deletion allele and severe obesity (Odds ratio = 0.18, 95% confidence interval: 0.07–0.44, P = 0.0004).
Conclusions: The present study reported that the frequency of UCP2 45-BP I/D polymorphisms in a population originating from eastern Saudi Arabia and identified a strong association between the D/D genotype and severe obesity.
Yahia A Kaabi
Institute of Researches and Consultation Services, Jazan University, 6433-Ash Shati, Unit No. 1, P. O. Box: 6433, Jazan
Kingdom of Saudi Arabia
|How to cite this article:|
Kaabi YA. The deletion polymorphism in exon 8 of uncoupling protein 2 is associated with severe obesity in a Saudi Arabian case–control study.Indian J Endocr Metab 2018;22:200-203
|How to cite this URL:|
Kaabi YA. The deletion polymorphism in exon 8 of uncoupling protein 2 is associated with severe obesity in a Saudi Arabian case–control study. Indian J Endocr Metab [serial online] 2018 [cited 2021 Apr 13 ];22:200-203
Available from: https://www.ijem.in/article.asp?issn=2230-8210;year=2018;volume=22;issue=2;spage=200;epage=203;aulast=Kaabi;type=0