Indian Journal of Endocrinology and Metabolism

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 23  |  Issue : 5  |  Page : 575--579

Disorders of sex development: A 10 years experience with 73 cases from the Kashmir Valley


Raiz Ahmad Misgar1, Moomin Hussain Bhat1, Shariq Rashid Masoodi1, Mir Iftikhar Bashir1, Arshad Iqbal Wani1, Aejaz Ahsan Baba2, Gowhar Nazir Mufti2 
1 Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India
2 Department of Paediatric Surgery, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India

Correspondence Address:
Raiz Ahmad Misgar
Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir
India

Purpose: To present the clinical data, investigative profile, and management of patients with disorders of sex development (DSD) from the endocrine unit of a tertiary care university hospital. Materials and Methods: This retrospective study included 73 cases of DSD, evaluated and managed at Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, over a period of 10 years from September 2008 to August 2018. Results: Twenty-nine patients (39.7%) had 46 XY DSD and twenty-nine patients (39.7%) had 46 XX. Sex chromosome DSD was diagnosed in 15 (20.5%) patients. Of 29 patients with 46 XY DSD, 17 (58.6%) had 5α-reductase type-2 deficiency (5α-RD) and 6 (20.7%) had complete androgen insensitivity syndrome. In our patients with 5α-RD, the history of consanguinity was documented in nine (52.9%) patients. Two patients had testosterone biosynthetic defect and one patient had partial androgen insensitivity syndrome. Of 29 patients with 46 XX DSD, 16 (55.1%) had congenital adrenal hyperplasia (CAH). Of 15 patients with sex chromosome DSD, 7 patients had Turner's syndrome, 7 had Klinefelter's syndrome, and 1 patient had mixed gonadal dysgenesis. Conclusion: In our study, equal number of patients had 46 XY DSD and 46 XX DSD. We are for the first time reporting from India that the most common cause of 46 XY DSD is 5α-RD, whereas CAH is the most common cause of 46 XX DSD as reported previously.


How to cite this article:
Misgar RA, Bhat MH, Masoodi SR, Bashir MI, Wani AI, Baba AA, Mufti GN. Disorders of sex development: A 10 years experience with 73 cases from the Kashmir Valley.Indian J Endocr Metab 2019;23:575-579


How to cite this URL:
Misgar RA, Bhat MH, Masoodi SR, Bashir MI, Wani AI, Baba AA, Mufti GN. Disorders of sex development: A 10 years experience with 73 cases from the Kashmir Valley. Indian J Endocr Metab [serial online] 2019 [cited 2021 Apr 16 ];23:575-579
Available from: https://www.ijem.in/article.asp?issn=2230-8210;year=2019;volume=23;issue=5;spage=575;epage=579;aulast=Misgar;type=0