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2013| November-December | Volume 17 | Issue 6
Online since
December 3, 2013
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REVIEW ARTICLES
Imaging of non alcoholic fatty liver disease: A road less travelled
Divya Singh, Chandan J Das, Manas P Baruah
November-December 2013, 17(6):990-995
DOI
:10.4103/2230-8210.122606
PMID
:24381873
Non alcoholic fatty liver disease (NAFLD) is a spectrum that includes simple steatosis, nonalcoholic steatohepatitis and cirrhosis. It is increasingly emerging as a cause of elevated liver enzymes, cryptogenic cirrhosis and hepatocellular carcinoma. The morbidity and mortality related to NAFLD is expected to rise with the upsurge of obesity and type 2 diabetes mellitus. The need of the hour is to devise techniques to estimate and then accurately follow-up hepatic fat content in patients with NAFLD. There are lots of imaging modalities in the radiological armamentarium, namely, ultrasonography with the extra edge of elastography, computed tomography, and magnetic resonance imaging with chemical shift imaging and spectroscopy to provide an estimation of hepatic fat content.
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47,528
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Atherogenic dyslipidemia
CN Manjunath, Jayesh R Rawal, Paurus Mehelli Irani, K Madhu
November-December 2013, 17(6):969-976
DOI
:10.4103/2230-8210.122600
PMID
:24381869
Atherogenic dyslipidemia (AD) refers to elevated levels of triglycerides (TG) and small-dense low-density lipoprotein and low levels of high-density lipoprotein cholesterol (HDL-C). In addition, elevated levels of large TG rich very low-density lipoproteins, apolipoprotein B and oxidised low-density lipoprotein (LDL), and reduced levels of small high-density lipoproteins plays a critical role in AD. All three elements of AD
per se
have been recognised as independent risk factor for cardiovascular disease. LDL-C/HDL-C ratio has shown excellent risk prediction of coronary heart disease than either of the two risk markers. Asian Indians have a higher prevalence of AD than western population due to higher physical inactivity, low exercise and diet deficient in polyunsaturated fatty acids (PUFA). The AD can be well managed by therapeutic lifestyle changes with increased physical activities, regular exercise, and diets low in carbohydrates and high in PUFA such as omega-3-fatty acids, as the primary intervention. This can be supplemented drug therapies such as statin monotherapy or combination therapy with niacin/fibrates. Rosuvastatin is the only statin, presently available, to effectively treat AD in diabetes and MS patients.
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5,078
1,136
Pregnancy and pituitary disorders: Challenges in diagnosis and management
Bashir A Laway, Shahnaz A Mir
November-December 2013, 17(6):996-1004
DOI
:10.4103/2230-8210.122608
PMID
:24381874
Pregnancy is associated with normal physiological changes in endocrine system that assists fetal survival as well as preparation of labor. The pituitary gland is one of the most affected organs in which major changes in anatomy and physiology take place. Due to overlapping clinical and biochemical features of pregnancy, sometimes the diagnosis of pituitary disorders may be challenging. It is important to know what normal parameters of changes occur in endocrine system in order to diagnose and manage complex endocrine problems in pregnancy. In our present review, we will focus on pituitary disorders that occur exclusively during pregnancy like Sheehan's syndrome and lymphocytic hypophysitis and pre-existing pituitary disorders (like prolactinoma, Cushing's disease and acromegaly), which poses significant challenge to endocrinologists.
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Management of statin intolerance
Soma B Raju, Kiron Varghese, K Madhu
November-December 2013, 17(6):977-982
DOI
:10.4103/2230-8210.122602
PMID
:24381870
Statins are the revolutionary drugs in the cardiovascular pharmacotherapy. But they also possess several adverse effects like myopathy with elevation of hepatic transaminases (>3 times the upper limit of normal) or creatine kinase (>10 times the upper limit of normal) and some rare side-effects, including peripheral neuropathy, memory loss, sleep disturbances, and erectile dysfunction. Due to these adverse effects, patients abruptly withdrew statins without consulting physicians. This abrupt discontinuation of statins is termed as statin intolerance. Statin-induced myopathy constitutes two third of all side-effects from statins and is the primary reason for statin intolerance. Though statin intolerance has considerably impacted cardiovascular outcomes in the high-risk patients, it has been well effectively managed by prescribing statins either as alternate-day or once weekly dosage regimen, as combination therapy with a non-statin therapy or and by dietary intervention. The present article reviews the causes, clinical implications of statin withdrawal and management of statin intolerance.
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ORIGINAL ARTICLES
Impact of lifestyle modification on glycemic control in patients with type 2 diabetes mellitus
Nandita B Sanghani, Deepak N Parchwani, Kamlesh M Palandurkar, Amit M Shah, Jatin V Dhanani
November-December 2013, 17(6):1030-1039
DOI
:10.4103/2230-8210.122618
PMID
:24381880
Background:
Current treatment guidelines support the role of lifestyle modification, in terms of increasing the quantity and quality of physical activity to achieve target glycemia in patients with type 2 diabetes mellitus.
Objective:
To assess the effect of structured exercise training and unstructured physical activity interventions on glycemic control.
Materials and Methods:
This was a randomized six-month exercise intervention study conducted with previously inactive 279 patients of type 2 diabetes mellitus. Before randomization, all enrolled T2DM participants (
n
: 300; 30 to 60 year old, having diabetes for more than a year with HbA1c levels of 6.5% or higher) entered a one-month run-in phase to reduce dropout and maintain adherence.
Results:
A recommendation to increase physical activity was beneficial (0.14% HbA1c reduction;
P
= 0.12), but was not bringing significantly declines in HbA1c, whereas, structured exercise training is associated with a significant HbA1c decline of 0.59%. (
P
= 0.030). In a subgroup analysis limited to participants with a baseline HbA1c value > 7%, both the unstructured (0. 48%;
P
= 0.04) and structured exercise training (0.77%;
P
< 0.01) groups experienced significant decline in HbA1c Vs the control, whereas among participants with baseline hemoglobin A1c values less than 7%, significant reduction occurred only in the structured exercise training group. Changes in blood pressure; total cholesterol, HDL-cholesterol (high-density lipoprotein), LDL-cholesterol (low-density lipoprotein) and the atherogenic index factors did not statistically significantly differ within (baseline to follow-up) and among groups.
Conclusion:
Supervised structured training was more efficacious than unstructured activity in achieving declines in HbA1c. Although both structured and unstructured training provide benefits, only the former was associated with significant reductions in HbA1c levels. Therefore, T2DM patients should be stimulated to participate in specifically designed exercise intervention programs.
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Longitudinal study on thyroid function in patients with thalassemia major: High incidence of central hypothyroidism by 18 years
Ashraf T Soliman, Fawzia Al Yafei, Lolwa Al-Naimi, Noora Almarri, Aml Sabt, Mohamed Yassin, Vincenzo De Sanctis
November-December 2013, 17(6):1090-1095
DOI
:10.4103/2230-8210.122635
PMID
:24381890
Introduction:
Primary hypothyroidism is one of the most frequent complications observed in-patients suffering from thalassemia. We investigated and reviewed the thyroid function in all thalassemic patients attending the Pediatric Endocrine Clinic of Hamad Medical Center, Doha, Qatar during the last 10 years of follow-up.
Patients and Methods:
A total of 48 patients with ί-thalassemia major between 5 years and 18 years of age. Thyroid dysfunction was defined as follows: Overt hypothyroidism (low Free thyroxine [FT4] and increased thyroid-stimulating hormone [TSH] levels >5 μIU/ml); subclinical hypothyroidism (normal FT4, TSH between 5 μIU/ml and 10 μIU/ml) and central (secondary) hypothyroidism (low FT4 and normal or decreased TSH).
Results:
A total of 48 patients (22 males and 26 females) completed a 12 year-period of follow-up. During this period, hypothyroidism was diagnosed in 17/48 (35%) of patients. There was no significant difference in the prevalence in males 7/22 (32%) versus females 10/26 (38%). Sixteen of the patients had hypothyroidism after the age of 10 years (94%). The prevalence of overt hypothyroidism had risen from 0% at the age of 7 years to 35% at the age of 18 years. None of the patients had high anti-thyroperoxidase antibody titers. Out of 17 patients, 13 patients with hypothyroidism had normal or low TSH level (not appropriately elevated) indicative of defective hypothalamic pituitary response to low FT4 (central hypothyroidism). Three patients (6.3%) had subclinical hypothyroidism (TSH between 5 uIU/ml and 10 uIU/ml and normal FT4). The general trend of FT4 level showed progressive decrease over the 12 years, whereas, TSH levels did not show a corresponding increase. These data suggested defective hypothalamic pituitary thyroid axis involving both TSH and FT4 sretion in patients with thalassemia major over time. There was a significant negative correlation between serum ferritin and FT4 (
r
= −0.39,
P
= 0.007), but no correlation was found between ferritin and TSH.
Conclusions:
Worsening of thyroid function was observed in 35% of the studied thalassemic patients by the age of 18 years. The lack of proper increase of TSH in response to the low circulating levels of FT4 in 13/17 (76%) of these patients indicates a relatively high incidence of defective pituitary thyrotrophic function in these patients.
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Growth status of children and adolescents with type 1 diabetes mellitus
Vaman V Khadilkar, Lavanya S Parthasarathy, Basavraj B Mallade, Anuradha V Khadilkar, Shashi A Chiplonkar, Ashwin B Borade
November-December 2013, 17(6):1057-1060
DOI
:10.4103/2230-8210.122623
PMID
:24381884
Background and Objectives:
Growth parameters are important indicators of a child's overall health, and they are influenced by factors like blood glucose control in diabetic children. Data on growth parameters of Indian diabetic children is scarce. This retrospective, cross-sectional, case control study was conducted at diabetes clinic for children at a tertiary care center at Pune, to study growth parameters of diabetic children in comparison with age-gender matched healthy controls and evaluate effect of different insulin regimes and age at diagnosis of diabetes on growth.
Materials and Methods:
One twenty five diabetic children (boys: 50) and age gender matched healthy controls were enrolled. All subjects underwent anthropometric measurements (standing height and weight). Mean height (HAZ), weight (WAZ) and body mass index (BAZ) for age Z scores were calculated. Diabetes control was evaluated by measuring glycosylated hemoglobin (HbA1C). Statistical analysis was done by SPSS version 12.
Results:
Mean age of diabetic children and age gender matched controls was 9.7 ± 4.4 years. Diabetic children were shorter (128.3 ± 24.3 cm vs. 133.6 ± 24.7 cm) and lighter (29.2 kg ± 15.3 vs. 31.3 ± 15.4 kg). HAZ (−1.1 ± 1.2 vs. −0.2 ± 0.8) and WAZ (−1.2 ± 1.3 vs. −0.7 ± 1.3) were significantly lower in diabetic children (
P
< 0.05). Children on both insulin regimes (intensive and conventional) were shorter than controls (HAZ-intensive −1.0 ± 1.0, conventional −1.3 ± 1.3, control −0.2 ± 0.8,
P
< 0.05). HAZ of children who were diagnosed at <3 years of age was the least (−1.6 ± 1) amongst all diabetic children while those diagnosed after puberty (>14 years) were comparable to healthy controls.
Conclusions:
Growth was compromised in diabetic children in comparison to controls. Children diagnosed at younger age need more attention to optimize growth.
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Proteus syndrome: Clinical diagnosis of a series of cases
Cresio Alves, Angelina X Acosta, Maria Betânia P Toralles
November-December 2013, 17(6):1053-1056
DOI
:10.4103/2230-8210.122621
PMID
:24381883
Objectives:
This paper describes the clinical diagnosis of Proteus syndrome (PS) in children referred for evaluation of asymmetric disproportionate overgrowth.
Materials and Methods:
Retrospective, descriptive, cross-sectional study conducted from January 1998 to December 2010.
Results:
During the study period, 2011 new patients were evaluated. Thirteen (0.65%) patients presented features suggestive of PS. These patients were formally evaluated based on the revised diagnostic criteria proposed by Biesecker. The mean age was 6.92 ± 5.1 years. Ten patients (76.9%) were females. All subjects had asymmetric disproportionate overgrowth. Other dysmorphic features were as follows: macrodactily (84.6%); linear epidermal nevus (41.6%); hemangioma (30.7%); and lipoma (23%). Six patients fulfilled the diagnostic criteria for PS.
Conclusions:
The diagnostic rate of only 46.1% of patients with PS confirms the diagnostic difficulties and the need for continuous monitoring and periodic review of these patients since the clinical manifestations of this syndrome become more evident with aging. Molecular tests may help the differential diagnosis of Proteus syndrome when they became commercially available.
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1,588
405
REVIEW ARTICLES
Plaque regression and plaque stabilisation in cardiovascular diseases
Tarun Dave, J Ezhilan, Hardik Vasnawala, Vinod Somani
November-December 2013, 17(6):983-989
DOI
:10.4103/2230-8210.122604
PMID
:24381872
Atherosclerosis is characterized by formation of plaques on the inner walls of arteries that threatens to become the leading cause of death worldwide via its sequelae of myocardial infarction and stroke. Endothelial dysfunction leads to cholesterol uptake and accumulation of infl ammatory markers within the plaque. The stability of a plaque eventually depends on the balance between vascular smooth muscle cells that stabilize it and the infl ammatory cells like macrophages and T lymphocytes that make it prone to rupture. The current approach to manage atherosclerosis focuses on the treatment of a ruptured plaque and efforts have been made to reduce the risk of plaque rupture by identifying vulnerable plaques and treating them before they precipitate into clinical events. New diagnostic approaches such as IVUS and CIMT ultrasound are now being preferred over traditional coronary angiography because of their better accuracy in measuring plaque volume rather than the level of stenosis caused. The present review highlights the literature available on two prevalent approaches to manage a vulnerable plaque, namely, plaque stabilization and plaque regression, and their validation through various treatment modalities in recent plaque management studies. Plaque stabilization focuses on stabilizing the content of plaque and strengthening the overlying endothelium, while plaque regression focuses on the overall reduction in plaque volume and to reverse the arterial endothelium to its normal functional state. Although earlier studies contemplated the practicality of plaque regression and focused greatly on stabilization of a vulnerable plaque, our review indicated that, aided by the use of superior diagnostics tools, more intensive lipid modifying therapies have resulted in actual plaque regression.
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BRIEF COMMUNICATIONS
Prevalence of thyroid function test abnormalities and thyroid autoantibodies in children with vitiligo
Fatma Sule Afsar, Figen Isleten
November-December 2013, 17(6):1096-1099
DOI
:10.4103/2230-8210.122636
PMID
:24381891
Although the exact pathogenic processes involved in vitiligo are still unknown, its association with autoimmune disorders and endocrine dysfunction has been reported. One of its associations is with thyroid diseases. The purpose of this retrospective study was to determine the prevalence of thyroid function tests and thyroid autoantibody abnormalities in children diagnosed with vitiligo and compare the results with the literature. The laboratory documents of thyroid function tests (FT3, FT4, and TSH) and thyroid autoantibodies (TgAb and TPOAb) belonging to the pediatric vitiligo patients were studied retrospectively. Thyroid function tests and thyroid autoantibody abnormalities were detected in 20 (25.3%) of the pediatric vitiligo patients. Thirteen (16.4%) patients were evaluated as subclinical hypothyroidism, two (2.5%) were evaluated as hypothyroidism, and five (6.3%) were evaluated as euthyroidism. Thyroid autoantibodies were found to be positive in nine (11.3%) patients. Previously reported prevalence of thyroid disease in children with vitiligo ranged from 10.7 to 24.1%, and the prevalence of 25.3% determined in this study was compatible with the literature. Also, the high rate of subclinical hypothyroidism determined in these patients attracted attention to the probable development of overt hypothyroidism in a long term. Thus, our results suggest that thyroid function tests and thyroid autoantibodies should be analyzed in children with vitiligo.
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CASE REPORTS
A case of autoimmune hypoglycemia outside Japan: Rare, but in the era of expanding drug-list, important to suspect
Krishan Gopal, Gagan Priya, Nandita Gupta, EP Praveen, Rajesh Khadgawat
November-December 2013, 17(6):1117-1119
DOI
:10.4103/2230-8210.122644
PMID
:24381896
We are hereby reporting a case of a 72-year-old Indian man, who, in the absence of a detectable tumor, presented with symptomatic hypoglycemia in the postabsorptive state (3-5 h after meal). His serum levels of insulin and C-peptide were very high. He was not taking any hypoglycemic drug. Hypoglycemic episodes completely subsided after withdrawal of pentoprazole and incorporation of small frequent meals in the dietary plan. Six months after the initial presentation, the subject became free of hypoglycemic episodes. Although insulin autoimmune syndrome (IAS) is the third leading cause of spontaneous hypoglycemia in Japan, it is extremely uncommon in the Western Countries. Till 2009, more than 200 cases from Japan and as many as 58 cases outside Asia have been reported. To the best of our knowledge, this is the first case of IAS reported from India.
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ORIGINAL ARTICLES
Emotional, behavioral and cognitive profile, and quality of life of Indian children and adolescents with type 1 diabetes
Kriti Puri, Savita Sapra, Vandana Jain
November-December 2013, 17(6):1078-1083
DOI
:10.4103/2230-8210.122631
PMID
:24381888
Background and Aims:
The psychological stress associated with type 1 diabetes (T1D) may be higher in children from developing world due to limited health resources. The aims of the study were to assess the quality of life (QoL), emotional well-being, behavioral, and cognitive profile of children/adolescents with T1D diagnosed at least 6 months prior.
Materials and Methods:
Forty-nine children with T1D, aged 6−18 years were assessed using DAWN Youth QoL questionnaire, WHO-5 Well-Being Index, Child Behavior Checklist (CBCL), and Malin's Intelligence Scale for Indian children (MISIC). The association of the scores was studied with age, gender, socioeconomic status (SES), frequency of hypoglycemia, HbA1c, and age of onset and duration of T1D.
Results:
The mean (standard deviation (SD)) for DAWN QoL, WHO-5, CBCL, and MISIC scores was 24.7 (16.7), 74.6 (19.4), 52.6 (8.8), and 96.0 (11.2), respectively. The significant associations noted were: Elevated HbA1c with poorer emotional well-being; higher negative impact on 'symptoms of disease' and 'future prospects' sub-areas of QoL; shorter duration of disease with more behavioral issues; lower maternal education with more 'withdrawn/depressed' behaviors and 'worry about future prospects'; and lower SES with lower MISIC scores. Earlier onset (age <5 years) was associated with fewer behavioral problems and less negative impact on QoL.
Conclusion:
Children with recent diagnosis, older age at onset, lower maternal educational level, elevated HbA1c, or belonging to lower SES were identified to have higher prevalence of various psychological and cognitive problems. In resource-limited settings, these children should be prioritized for behavioral and cognitive evaluation.
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462
Increased risk of type 2 diabetes with ascending social class in urban South Indians is explained by obesity: The Chennai urban rural epidemiology study (CURES-116)
Mette Skar, Anne Berg Villumsen, Dirk Lund Christensen, Joergen Holm Petersen, Mohan Deepa, Ranjit Mohan Anjana, Rajendra Pradeepa, Viswanathan Mohan
November-December 2013, 17(6):1084-1089
DOI
:10.4103/2230-8210.122632
PMID
:24381889
Aim:
The aim of this study is to determine the factors responsible for differences in the prevalence of diabetes mellitus (DM) in subjects of different social class in an urban South Indian population.
Materials and Methods:
Analyses were based on the cross-sectional data from the Chennai Urban Rural Epidemiology Study of 1989 individuals, aged ≥20 years. Entered in the analyses were information obtained by self-report on (1) household income; (2) family history of diabetes; (3) physical activity; (4) smoking status; (5) alcohol consumption. Biochemical, clinical and anthropometrical measurements were performed and included in the analyses. Social class was classified based on income as low (Rs. <2000) intermediate (Rs. 2000-5000`) and high (Rs. 5000-20000).
Results:
The prevalence rates of DM were 12.0%, 18.4% and 21.7% in low, intermediate and high social class, respectively (
P
< 0.001). A significant increase in the risk of diabetes was found with ascending social class (Intermediate class: Odds ratio [OR], 1.7 [confidence interval [CI], 1.2-2.3]; High class: OR, 2.0 [CI-1.4-2.9]). The multivariable adjusted logistic regression analysis revealed that the effect of social class on the risk of diabetes remained significant (
P
= 0.016) when age, family history of diabetes and blood pressure were included. However, with the inclusion of abdominal obesity in the model, the significant effect of social class disappeared (
P
= 0.087).
Conclusion:
An increased prevalence of DM was found in the higher social class in this urban South Indian population, which is explained by obesity.
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The effects of an exercise training program on body composition and aerobic capacity parameters in Tunisian obese children
Sofien Regaieg, Nadia Charfi, Mahdi Kamoun, Sameh Ghroubi, Haithem Rebai, Habib Elleuch, Mouna Mnif Feki, Mohamed Abid
November-December 2013, 17(6):1040-1045
DOI
:10.4103/2230-8210.122619
PMID
:24381881
Background:
The prevalence of children obesity is rising alarmingly in both developed and developing countries. Developing effective exercise programs is a strategy for decreasing this prevalence and limiting obesity-associated long-term comorbidities.
Objectives:
To determine whether a 16-week training program; in addition to the school physical education and without dietary intervention; could have beneficial effects on body composition and aerobic capacity of obese children.
Materials and Methods:
Twenty-eight obese children (16 boys, 12 girls; aged 12-14 years) were enrolled and were divided into either the exercise group (EG,
n
= 14) or the control group (CG,
n
= 14). EG participated in a 16-week aerobic exercises (four 60-min sessions per week at 70-85% of HRmax (maximum heart rate)), in addition to the school physical education. Fat-Free Mass (FFM) and Fat Mass (FM) were assessed with bioelectrical impedance equipment. To assess aerobic capacity, maximal metabolic equivalent of task (METmax) and maximal workload (Wmax) were estimated with an electronically braked cycle ergometer (type Ergoline 500
®
).
Results:
At baseline, there were no differences between the two groups. After the training program, only the EG showed significant reduction in BMI (body mass index) and waist circumference compared with the baseline values (
P
< 0.001). Exercise training significantly decreased FM only in the EG. A significant increase in FFM was seen in both groups; more marked in the EG. There was a significant increase in METmax (
P
< 0.05) and Wmax (
P
= 0.02) in the EG, and no significant changes in these parameters were seen in the CG. HRmax significantly decreased only in the EG (
P
< 0.05).
Conclusion:
This training program has beneficial effects on body composition and aerobic capacity parameters in obese children. Our intervention has the advantage of providing a sustainable and reproducible school and community approach for the management of children obesity.
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531
ENDOCRINOLOGY AND GENDER
Prevalence of gestational diabetes mellitus and its correlation with blood pressure in Manipuri women
Vanlalhruaii , Salam Ranabir, Lallan Prasad, Naorem Nabakishore Singh, Thangjam Premchand Singh
November-December 2013, 17(6):957-961
DOI
:10.4103/2230-8210.122597
PMID
:24381867
Objective:
The aim and objective was to study the prevalence of gestational diabetes mellitus (GDM) by using National Diabetes Data Group (NDDG) and American Diabetes Association (ADA) (2004) criteria and the correlation of GDM with gestational blood pressure (BP) and maternal age.
Study Design:
This was a cross-sectional study in which 300 pregnant women in 24-28 weeks of pregnancy who screened positive with 1-h glucose load ≥ 140 mg/dL underwent a diagnostic 3-h oral glucose tolerance test (OGTT). BP was obtained by review of the medical records.
Results:
Thirty-seven (12.33%) women were screened positive with 50 g glucose challenge test (GCT) (≥140 mg%) out of the 300 participants. With 100 g 3-h OGTT among these 37 women, none of them fulfilled the NDDG diagnostic criteria for GDM. However, on using the ADA (2004) criteria, three (8.1%) women were diagnosed to have GDM. All three of them had systolic BP between 120 and 139 mmHg; two of them had diastolic BP between 80 and 89 mmHg. Among 37 subjects with GCT > 140 mg%, majority were older than 26 years.
Conclusion:
Using the ADA (2004) guideline, 1% of the total study population had GDM. The BP of these patients fell within the prehypertensive range, thus suggesting an association between GDM and BP.
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333
ORIGINAL ARTICLES
Cortisol response to low dose versus standard dose (back-to-back) adrenocorticotrophic stimulation tests in children and young adults with thalassemia major
Ashraf T Soliman, Mohamed Yassin, Nadra M. S. Abdel Majuid, Aml Sabt, Mohamed O Abdulrahman, Vincenzo De Sanctis
November-December 2013, 17(6):1046-1052
DOI
:10.4103/2230-8210.122620
PMID
:24381882
Background:
Thalassemia major patients with repeated blood transfusion have high prevalence of endocrinopathies due to iron overload.
Materials and Methods:
We examined the adrenocortical function in 23 thalassemic patients (10 children and 13 young adults) aged 8-26 years. Serum cortisol and dehydroepiandrosterone sulfate (DHEA-S) concentrations were determined in each subject before blood transfusion both in basal condition and after low dose (LD) (1 μg), followed by standard dose (SD) (250 μg, respectively) with synthetic corticotrophin beta 1-24 ACTH (Synacthen, Ciba). Normal controls were a group of 13 age- and sex-matched normal subjects.
Results:
Using a peak total cortisol cutoff level of 550 nmol/L and increments of 200 μg above basal cortisol, adrenal insufficiency (AI) was demonstrated in 8 patients (34.7%) after the LD ACTH and in 2 patients (8.7%) after SD cosyntropin (ACTH) test, but none of the controls. Using a peak total cortisol cutoff level of 420 nmol/L and increments of 200 μg above basal cortisol, AI was demonstrated in 5 patients (21.7%) after the LD ACTH and in 2 patients after SD ACTH test (8.7%), but none of controls. All patients with biochemical AI were asymptomatic with normal serum sodium and potassium concentrations and had no history suggestive of adrenal pathology. The peak cortisol concentrations in thalassemic patients with impaired adrenal function both after 1 μg and 250 μg cosyntropin (294 ± 51 nmol/L and 307 ± 58.6) were significantly lower than those with patients with normal (454 ± 79.7 nmol/L and 546.1 ± 92.2 nmol/L, respectively) and controls (460.2 ± 133.4 nmol/L and 554.3 ± 165.8 nmol/L, respectively). Adolescents and young adults, but not children with thalassaemia, had significantly lower peak cortisol concentration after SD ACTH versus controls. Peak cortisol response to LD ACTH was correlated significantly with peak cortisol response to SD in all patients (
r = 0.83, P
< 0.0001). In adolescents and young adults with thalassemia, DHEA-S levels before and after LD ACTH stimulation were significantly lower and the cortisol/DHEA-S ratios were significantly higher than the controls.
Conclusion:
The use of LD ACTH test diagnoses more adrenal abnormalities versus SD ACTH in thalassemic patients. The relatively high prevalence of AI in thalassemic adolescents and young adults necessitates that these patients have to be investigated for AI before major surgery and those with impaired cortisol secretion should receive stress doses of corticosteroids during the stressful event.
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320
REVIEW ARTICLES
Diabetes conversation map in Nigeria: A new socioeducational tool in diabetes care
Sunny Chinenye, Ekene E Young
November-December 2013, 17(6):1009-1011
DOI
:10.4103/2230-8210.122613
PMID
:24381876
The importance of diabetes education in the management of patients is very crucial. One-on-one education, didactic group lectures are traditional methods employed in Diabetes Education. In our environment, group interaction using the Diabetes Conversation Map tools may prove to be effective especially during regular meetings of the Diabetes Association.
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BRIEF COMMUNICATIONS
Disparity in cholecalciferol content of commercial preparations available in India
Rajesh Khadgawat, Rekha Ramot, KM Chacko, RK Marwaha
November-December 2013, 17(6):1100-1103
DOI
:10.4103/2230-8210.122638
PMID
:24381892
Background:
High prevalence of vitamin D deficiency (VDD) has been reported throughout the India for all age groups. Increased awareness about VDD among treating physicians has led to increased prescriptions of vitamin D preparations. Based on our experience of varied clinical and radiological response with different vitamin D formulations, we decided to assess cholecalciferol content of commonly available vitamin D formulations.
Materials and Methods:
We measured cholecalciferol content of 14 commercial preparations (two in the form of tablets and 12 as sachet) available in Indian market. Lab analysis was carried out in Shriram Institute for Industrial Research by high-performance liquid chromatography.
Results:
Of the total 14 samples analyzed only 4 (28.57%) were found to be within the acceptable ranges from −90 to +125% as defined by Indian Pharmacopia while 5 (35.7%) had higher and 5 (35.7%) had lower than the acceptable range. The percentage variation in cholecalciferol content as observed from the printed ranged widely from −91% to +65%.
Conclusions:
Our study shows a high degree of variability in cholecalciferol content of commercial preparations available in the Indian pharmaceutical market. This variation has many clinical implications as it may lead both, under treatment as well as vitamin D toxicity.
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ENDOCRINOLOGY AND GENDER
Does blood transfusion affect pituitary gonadal axis and sperm parameters in young males with sickle cell disease?
Ashraf T Soliman, Mohamed Yasin, Ahmed El-Awwa, Mohamed O Abdelrahman, Vincenzo De Sanctis
November-December 2013, 17(6):962-968
DOI
:10.4103/2230-8210.122599
PMID
:24381868
Objective:
We evaluated the effect of packed red cell transfusion (PCTx) on serum concentrations of gonadotropins luteinizing hormone and follicle-stimulating hormone (LH and FSH) and testosterone (T) levels and measured sperm parameters in young adults with sickle cell disease (SCD) on top-up transfusion (TTx) and those on exchange transfusion (ETx) regimen.
Materials
and
Methods:
Basal serum concentrations of FSH, LH, and T and semen parameters were evaluated before and 7 days after PCTx in 18 young adults with transfusion-dependent SCD, aged 20.7 ± 2.88 years. They had full pubertal development (Tanner's stage 5), and capacity to ejaculate. They were regularly transfused since early childhood. Chelation therapy was started early during the first 2 years of life using desferrioxamine and was replaced by deferasirox for the last 4-5 years. Ten patients were on TTx and eight were on ETx regimen.
Results:
PCTx significantly increased hemoglobin (Hb) from 8.5 ± 1.17 g/dl to 10.5 ± 0.4 g/dl, T from 12.3 ± 1.24 nmol/L to 14.23 ± 1.22 nmol/L and gonadotropins' concentrations. Sperm parameters improved significantly after PCTx including: total sperm count from 87.4 ± 24.6 million/ml to 146.2 ± 51.25 million/ml, total progressive sperm motility (TPM) from 40.8 ± 11.1 million/ml to 93.4 ± 38.3 million/ml, rapid progressive sperm motility (RPM) progressive motility from 29.26 ± 8.75 million/ml to 67.4 ± 29 million/ml. After PCTx the total sperm count, TPM and RPM were significantly better in the ETx group versus the TTx group. Before and after PCTx, T concentrations were correlated significantly with sperm total count, volume, TPM and RPM (
r
= 0.53, 0.55, 0.42, and 0.38, respectively,
P
< 0.01). Hb concentrations were correlated significantly with sperm count, TPM, RPM, and % of sperms with normal morphology (
r
= 0.60, 0.69, 0.66, and 0.86, respectively,
P
< 0.001).
Conclusion:
Our study suggests that in males with SCD blood transfusion is associated with significant acute enhancement of sperm parameters and with increased concentrations of serum T, LH, and FSH. Improvement of sperm parameters were significantly better in the ETx group verses the TTx group. These "acute" effects on spermiogenesis are reached with an unknown mechanism/s and suggest a number of pathways that need further human and/or experimental studies.
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ORIGINAL ARTICLES
Dietary beliefs and eating patterns influence metabolic health in type 2 diabetes: A clinic-based study in urban North India
Susan L Colles, Shweta Singh, Chhavi Kohli, Ambrish Mithal
November-December 2013, 17(6):1066-1072
DOI
:10.4103/2230-8210.122626
PMID
:24381886
Background:
Almost 15% of India's urban adult populace now lives with type 2 diabetes. This study aimed to characterize the eating patterns, knowledge, beliefs, and determinants of food choice, and assess associations with the metabolic health among urban Asian Indians with type 2 diabetes.
Materials and Methods:
A cross-sectional study of 258 individuals (mean age 55.7 ± 10 years; body mass index 27.1 ± 4.8 kg/m
2
; diabetes duration 10.1 ± 6.5 years) attending two out-patient clinics in New Delhi, India. Food-related information was collected during a semi-structured interview. Clinical, anthropometric, and biochemical data were recorded.
Results:
Beliefs related to health and diabetes played a role determining food choice and dietary patterns; erroneous views were associated with the poor food choices and greater metabolic perturbations. Average consumption of fruits/vegetables was low. Intakes were positively associated with intentions to manage diabetes; inversely associated with the waist circumference and negatively correlated with one's degree of personal responsibility for food choice. Household saturated fat usage was common. High fat intakes were positively associated with the taste preference, ratings of perceived "health-value;" waist circumference, glycosylated haemoglobin percentage (HbA1c%) and lipids.
Conclusions:
Strategies to enhance diabetes control among Asian Indians are required and should encourage fruit/vegetable intake, personal accountability, and consider individual beliefs and preferences. Greater emphasis and resources directed to regular dietary and behavioral counseling may assist.`
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Association of serum testosterone with lipid abnormalities in patients with angiographically proven coronary artery disease
Chandima Madhu Wickramatilake, Mohamed Rifdy Mohideen, Chitra Pathirana
November-December 2013, 17(6):1061-1065
DOI
:10.4103/2230-8210.122624
PMID
:24381885
Context:
Low testosterone levels are associated with an atherogenic lipid profile and may contribute to the pathogenesis of atherosclerosis.
Aims:
Our study aimed to investigate the relationship between serum total testosterone (TT) levels and lipid profile in angiographically confirmed coronary artery disease (CAD) in men.
Settings and Design:
This is a case-control hospital-based study at Teaching Hospital, Karapitiya, Galle, Sri Lanka.
Materials and Methods:
Two hundred and six men, 103 with angiographically proven CAD and 103 healthy men as a control group were studied. The serum levels of TT and lipids were assessed.
Statistical Analysis:
Data were analyzed using Minitab software (version 15 for Windows).
Results:
The mean concentrations of lipid parameters of patients and controls were as follows: Serum total cholesterol (TCh), 5.9 ± 2.8 vs. 5.2 ± 1.6 mmol/l (
P
= 0.022), low-density lipoprotein cholesterol (LDL-Ch), 3.9 ± 1.2 vs. 3.1 ± 0.5 mmol/l (
P
= 0.001), high-density lipoprotein cholesterol (HDL-Ch), 1.1 ± 0.5 vs. 1.4 ± 0.6 mmol/l (
P
= 0.001), and TGs, 2.0 ± 1.0 vs. 1.5 ± 0.8 mmol/l (
P
= 0.001); lipid levels were significantly different between the two groups. The mean levels of TT in the patients and controls were 11.4 ± 2.7 vs. 18.1 ± 7.2 nmol/l (
P
= 0.001), significantly different. Among CAD patients, a significant positive association was found between testosterone and HDL-Ch (
r
= 0.623,
P
= 0.001), whereas a negative association was found with LDL-Ch (
r
= -0.579,
P
= 0.001).
Conclusions:
Low levels of TT in men with CAD that appear together with an atherogenic lipid milieu may be involved in the pathogenesis of CAD. The observed association between testosterone and HDL-Ch suggests a protective effect of the hormone.
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1,581
268
CD4 count as a predictor of adrenocortical insufficiency in persons with human immunodeficiency virus infection: How useful?
Ifedayo A Odeniyi, Olufemi A Fasanmade, Michael O Ajala, Augustin E Ohwovoriole
November-December 2013, 17(6):1012-1017
DOI
:10.4103/2230-8210.122615
PMID
:24381877
Objective:
To determine the usefulness of CD4 count in predicting adrenocortical insufficiency (AI) in persons with HIV infection.
Design:
Experimental study involving people with HIV infection and healthy people.
Participants:
The participants were recruited from the Lagos University Teaching Hospital. Forty-three newly diagnosed, treatment naive persons with HIV (23 males and 20 females) and 70 (35 males and 35 females) HIV negative subjects completed the study.
Intervention:
One microgram Synacthen
®
was given intravenously to stimulate the adrenal glands.
Main Outcome Measures:
Blood was collected for cortisol at 0 and 30 min after the injection of adrenocorticotropic hormone (ACTH) and CD4 count.
Results:
Mean basal cortisol was 154.9 ± 27.2 nmol/L and 239.9 ± 31.6 nmol/L (
P
< 0.001); the 30-min post ACTH test, cortisol level was 354.8 ± 19.9 nmol/L and 870.9 ± 163.5 nmol/L (
P
< 0.001); the increment was 100.0 ± 17.2 nmol/L and 588.8 ± 143.4 nmol/L (
P
< 0.001) in HIV and healthy subject group; respectively. Using the diagnostic criteria for diagnosis of AI in this study, fifteen (34.8%) persons with HIV had AI. There was no significant correlation between basal cortisol levels and CD4 count in patients with HIV infection (r = -0.2,
P
= 0.198). There was no significant correlation between stimulated cortisol level and CD4 count in patients with HIV infection (r = -0.09,
P
= 0.516).
Conclusion:
CD4 count does not predict the presence or absence of AI. ACTH stimulation of the adrenal gland remains the acceptable standard.
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301
Changes in brainstem auditory evoked potentials among North Indian females with Type 2 diabetes mellitus
Pooja Baweja, Sharat Gupta, Shallu Mittal, Avnish Kumar, Kamal Dev Singh, Raghuvansh Sharma
November-December 2013, 17(6):1018-1023
DOI
:10.4103/2230-8210.122616
PMID
:24381878
Background:
Diabetes mellitus is a complex metabolic disorder whose detrimental effects on various organ systems, including the nervous system are well known.
Aim:
This study was conducted to determine the changes in the brainstem auditory evoked potentials (BAEP) in patients with type 2 diabetes mellitus.
Materials and Methods:
In this case-control study, 116 females with type 2 diabetes and 100 age matched, healthy female volunteers were selected. The brainstem auditory evoked potentials (BAEP) were recorded with RMS EMG EP Marc-II Channel machine. The measures included latencies of waves I, II, III, IV, V and Interpeak latencies (IPL) I-III, III-V and I-V separately for both ears. Data was analysed statistically with SPSS software v13.0.
Results:
It was found that IPL I-III was significantly delayed (
P
= 0.028) only in the right ear, while the latency of wave V and IPL I-V showed a significant delay bilaterally (
P
values for right ear being 0.021 and 0.0381 respectively while those for left ear being 0.028 and 0.016 respectively), in diabetic females. However, no significant difference (
P
> 0.05) was found between diabetic and control subjects as regards to the latencies of waves I, II, III, IV and IPL III-V bilaterally and IPL I-III unilaterally in the left ear. Also, none of the BAEP latencies were significantly correlated with either the duration of disease or with fasting blood glucose levels in diabetics.
Conclusions:
Therefore, it could be concluded that diabetes patients have an early involvement of central auditory pathway, which can be detected quite accurately with the help of auditory evoked potential studies.
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Assessment of serum levels of soluble CD40L in Egyptian children and adolescents with type 1 diabetes mellitus: Relationship to microalbuminuria and glycemic control
Kotb Abbass Metwalley, Hekma Saad Farghaly, Abdel-Rahman Abdel-Hamed El-Saied
November-December 2013, 17(6):1024-1029
DOI
:10.4103/2230-8210.122617
PMID
:24381879
Context:
Soluble CD40 ligand (sCD40L) is known to be elevated in different clinical situations including hypercholesterolemia, acute coronary syndromes, and type 2 diabetes mellitus (T2DM), Data about the relationship between type 1 diabetes mellitus (T1DM) and sCD40L is limited. In addition, the potential role ofsCD40Lin the pathogenesis of vascular complications in children and adolescents with T1DM is to be clarified. Hence, the study aimed at assessment of sCD40L levels in children and adolescents with T1DM and correlation of these levels with glycemic control and microalbuminuria.
Settings and Design:
Cross-sectional controlled study.
Materials and Methods:
The study was performed in the Pediatric Endocrinology and Diabetes Unit, Assuit University Children Hospital, Assiut, Egypt. It included 70 children and adolescents with T1DM (mean age 14. 76 ± 2.21 years). Cases were further subdivided into 43 cases with normoalbuminuria and 27 cases with microalbuminuria according to presence or absence or microalbuminuria in fresh urine samples. Twentyfive healthy subjects, age- and sex-matched were included as control group (mean age = 13.62 ± 2.11 years). Studied cases were subjected to medical history, clinical examination, and laboratory assessment of fasting blood glucose (FBG), lipid profile, glycosylated hemoglobin (HbA1c), and sCD40L were performed.
Results:
Mean HbA1c and sCD40L were significantly higher in diabetic children (
n
= 70) compared to control (
n
= 25) (
P
< 0.001 for each). Mean HbA1c and sCD40L levels were significantly higher in microalbuminuric cases (
n
= 27) compared to normoalbuminuric cases (
n
= 43) (
P
< 0.05 and <0.01, respectively).We also observed a significant positive correlation between sCD40L levels and the age, diabetes duration, HbA1c, and urinary albumin creatinine ratio.
Conclusions:
The high serum sCD40L levels in children and adolescents with T1DM particularly in those with microalbminuria and its positive correlation with diabetes duration, urinary albumin excretion, and glycemic control may reflect the role of sCD40L in diabetic vasculopathy in the pediatric age group. Moreover, measurement of serum sCD40L levels in poorly controlled patients would help to identify those at high risk of developing nephropathy.
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241
Type-2 diabetes mellitus and auditory brainstem response
Sheelu S Siddiqi, Rahul Gupta, Mohd Aslam, Syed Abrar Hasan, Shakeel Ahmad Khan
November-December 2013, 17(6):1073-1077
DOI
:10.4103/2230-8210.122629
PMID
:24381887
Objective:
Diabetes mellitus (DM) causes pathophysiological changes at multiple organ system. With evoked potential techniques, the brain stem auditory response represents a simple procedure to detect both acoustic nerve and central nervous system pathway damage. The objective was to find the evidence of central neuropathy in diabetes patients by analyzing brainstem audiometry electric response obtained by auditory evoked potentials, quantify the characteristic of auditory brain response in long standing diabetes and to study the utility of auditory evoked potential in detecting the type, site, and nature of lesions.
Design:
A total of 25 Type-2 DM [13 (52%) males and 12 (48%) females] with duration of diabetes over 5 years and aged over 30 years. The brainstem evoked response audiometry (BERA) was performed by universal smart box manual version 2.0 at 70, 80, and 90 dB. The wave latency pattern and interpeak latencies were estimated. This was compared with 25 healthy controls (17 [68%] males and 8 [32%] females).
Result:
In Type-2 DM, BERA study revealed that wave-III representing superior olivary complex at 80 dB had wave latency of (3.99 ± 0.24) ms
P
< 0.001, at 90 dB (3.92 ± 0.28) ms
P
< 0.001 compared with control. The latency of wave III was delayed by 0.39, 0.42, and 0.42 ms at 70, 80, and 90 dB, respectively. The absolute latency of wave V representing inferior colliculus at 70 dB (6.05 ± 0.27) ms
P
< 0.001, at 80 dB (5.98 ± 0.27)
P
< 0.001, and at 90 dB (6.02 ± 0.30) ms
P
< 0.002 compared with control. The latency of wave-V was delayed by 0.48, 0.47, and 0.50 ms at 70, 80, and 90 dB, respectively. Interlatencies I-III at 70 dB (2.33 ± 0.22) ms
P
< 0.001, at 80 dB (2.39 ± 0.26) ms
P
< 0.001, while at 90 dB (2.47 ± 0.25) ms
P
< 0.001 when compared with control. Interlatencies I-V at 70 dB (4.45 ± 0.29) ms
P
< 0.001 at 80 dB (4.39 ± 0.34) ms
P
< 0.001, and at 90 dB (4.57 ± 0.31) ms
P
< 0.001 compared with control. Out of 25 Type-2 DM, 13 (52%) had diabetic neuropathy, of which 12 (92%) showed abnormal BERA. In nonneuropathic [12 (48%)] only 6 (50%) showed abnormal BERA.
Conclusion:
Delay in absolute latencies and interpeak latencies by BERA demonstrates defect at level of brainstem and midbrain in long standing Type-2 diabetes subjects, which is more pronounced in those with neuropathy.
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405
CASE REPORTS
Nelson's syndrome presenting as bilateral oculomotor palsy
Abhay Gundgurthi, Sandeep Kharb, MK Garg, KS Brar, Reena Bharwaj, HC Pathak, Maneet Gill
November-December 2013, 17(6):1114-1116
DOI
:10.4103/2230-8210.122643
PMID
:24381895
Nelson's syndrome refers to a clinical spectrum arising from progressive enlargement of pituitary adenoma and elevated adrenocorticotrophic hormone after total bilateral adrenalectomy for Cushing's disease comprising of hyperpigmentation, visual field defects which can be life threatening. We report here a 50-year male presenting with rapid onset of Nelson's syndrome with an unusual finding of bilateral oculomotor palsy mistakenly treated as ocular myasthenia.
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220
CASE REPORTS WITH REVIEW OF LITERATURE
Hyperthyroidism: A rare cause of pulmonary embolism: Report of two cases
Sonia Grine, Nadia Charfi, Mahdi Kamoun, Fatma Mnif, Basma Ben Naceur, Nabila Rekik, Mouna Mnif, Mohamed Abid
November-December 2013, 17(6):1104-1107
DOI
:10.4103/2230-8210.122640
PMID
:24381893
Several disorders of coagulation and fibrinolysis have been widely reported in patients with hyperthyroidism. Most reports have focused on only the venous thromboembolism risk, and few of them have studied specifically the association between hyperthyroidism and pulmonary embolism (PE). We report two cases of Graves' disease complicated by PE. The first patient is a 32 year-old man, and the second patient is a 23-year-old female. PE was suspected on the basis of pulmonary hypertension in patient one, and clinical presentation in the other patient. The first patient had also right heart failure. PE was confirmed in both patients by a lung perfusion-ventilation scan test. Thrombophilia screen revealed normal findings in the first patient and an elevation in coagulation factor VIII in the second one. Both patients received heparin, followed by oral anticoagulant therapy. In addition, they were treated with radioactive iodine resulting in partial recovery from hyperthyroidismforpatient oneand clinical euthyroidism for patient two.The former died of acute heart failure secondary to a chest infection, while the later was lost to follow-up. In conclusion, hyperthyroidism is associated with increased risk of venous thromboembolism, including PE. Potential mechanisms involved in this association include endothelial dysfunction, decreased fibrinolytic activity, and increased coagulation factors levels. Thyroid evaluation is recommended in patients with unprovoked venous thromboembolic events. Conversely, the diagnosis of venous thromboembolism should be considered in patients with hyperthyroidism, particularly if additional prothrombotic risk factors are present.
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1,618
390
EDITORIALS
New avatars in endocrine practice: The bariatric physician
Mathew John, Koshy George, Sanjay Kalra
November-December 2013, 17(6):953-954
DOI
:10.4103/2230-8210.122594
PMID
:24381865
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1
1,337
274
LETTERS TO THE EDITOR
Temozolomide: Anti-tumor effect on giant, invasive and resistant pediatric prolactinoma
Farida Chentli, Fetta-Amel Yaker, Said Azzoug, Faiza Belhimer
November-December 2013, 17(6):1136-1138
DOI
:10.4103/2230-8210.122657
PMID
:24381907
[FULL TEXT]
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1
983
252
Pragmatic use of metformin in pregnancy based on biopsychosocial model of health
Bharti Kalra, Yashdeep Gupta
November-December 2013, 17(6):1133-1135
DOI
:10.4103/2230-8210.122654
PMID
:24381904
[FULL TEXT]
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1
1,033
280
Audit on diabetes care in a secondary hospital in South India
Sajitha M. F. Rahman, Kirubah V David, Ruby A Priscilla, Sharon Cynthia
November-December 2013, 17(6):1130-1132
DOI
:10.4103/2230-8210.122650
PMID
:24381901
[FULL TEXT]
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1
892
215
CASE REPORTS
Sarcomatous transformation (Leiomyosarcoma) in polyostotic fibrous dysplagia
MK Garg, Reena Bhardwaj, Srishti Gupta, Navdeep Mann, Sandeep Kharb, Aditi Pandit
November-December 2013, 17(6):1120-1123
DOI
:10.4103/2230-8210.122645
PMID
:24381897
Malignant changes in polyostotic fibrous dysplasia are very rare. Most common malignancies reported are osteosarcoma and fibrosarcoma, chondrosarcoma and malignant fibrous histiocytoma. Here, we report a previously diagnosed case of fibrous dysplasia who has developed leiomyosarcoma; diagnosis of which was delayed for about one year despite repeated fine needle aspiration and open biopsy.
[ABSTRACT]
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1,335
280
An unusual case of paraganglioma
S Sridhar, V Parghi
November-December 2013, 17(6):1124-1126
DOI
:10.4103/2230-8210.122647
PMID
:24381898
Pheochromocytomas or Paragangliomas are neroendocrine tumors elaborating catecholamines. They may not present always in a classic manner and a high degree of suspicion is important in diagnosing them early. They can grow large enough to impinge on the great vessels and yet symptoms may not indicate the severity until late. A young African 32 year old Male presented with occasional headaches, moderate weight loss, abdominal pain and hypertension for three years. On investigation for hypertension a large paraganglioma was discovered wrapped around the Aorta and vena cava. He was operated successfully after preoperative preparation and was discharged normotensive.
Conclusion:
Young hypertensive should always be worked up fully including checking for abdominal masses. The classic paroxysm was absent in this case. After surgical removal the catecholamines elaborated by the tumor also take time to be washed out of the circulation thus the blood pressure will need careful monitoring. Conventional alpha blockage fi rst and beta blockage later was the algorithm followed but choice of agent was also discussed with nesthethesiologist. Though classically taught phenoxy benzamine is used, in this case it was not used and a combination of Prazosin and Propranolol was used successfully.
[ABSTRACT]
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989
207
Spinal polyostotic fibrous dysplasia in two adults: Does only biopsy unravel the mystery?
Abhay Gundgurthi, MK Garg, Reena Bhardwaj, Sandeep Kharb, Aditi Pandit, Karninder S Brar, Ravi Kumar, AG Pandit
November-December 2013, 17(6):1108-1113
DOI
:10.4103/2230-8210.122641
PMID
:24381894
Polyostotic fibrous dysplasia is a rare non-inheritable genetic disease due to mutation in GNAS gene. Here we present two adults who were accidentally detected lytic lesions in spine and after extensive evaluation for malignancies; was diagnosed on biopsy. Current concept of the disease and management is discussed.
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3,792
279
EDITORIALS
South Asian Federation of Endocrine Societies: A beginning well begun
Sanjay Kalra, Rakesh Kumar Sahay, Sarita Bajaj
November-December 2013, 17(6):955-956
DOI
:10.4103/2230-8210.122596
PMID
:24381866
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961
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ERRATUM
Erratum
November-December 2013, 17(6):1004-1004
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563
108
Erratum
November-December 2013, 17(6):982-982
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469
108
LETTERS TO THE EDITOR
Research methodology and publications: Are we following the correct science?
Sunil Kumar Raina, Sujeet Raina
November-December 2013, 17(6):1135-1135
DOI
:10.4103/2230-8210.122655
PMID
:24381905
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772
210
Prevalence of metabolic syndrome in adolescents: Reason to worry
Suresh Kumar Angurana, Renu Suthar Angurana
November-December 2013, 17(6):1135-1136
DOI
:10.4103/2230-8210.122656
PMID
:24381906
[FULL TEXT]
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691
179
Hypokalemic paralysis as the presenting manifestation of diabetes in two patients
Deepak S Amalnath, Tarun Kumar Dutta
November-December 2013, 17(6):1127-1128
DOI
:10.4103/2230-8210.122648
PMID
:24381899
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731
187
Incremental value of SPECT/CT over planar bone scan in the evaluation of skull base osteomyelitis: A potentially fatal disease in diabetics
Nishikant A Damle, Vrushali V Patwardhan, Arundeep Arora
November-December 2013, 17(6):1128-1129
DOI
:10.4103/2230-8210.122649
PMID
:24381900
[FULL TEXT]
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1,766
321
Insulin pump: A popular device for management of type 1 diabetes mellitus
Gaurav Atreja
November-December 2013, 17(6):1132-1133
DOI
:10.4103/2230-8210.122651
PMID
:24381902
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Antidyslipidemic drugs in metabolic syndrome
Anant D Patil
November-December 2013, 17(6):1133-1133
DOI
:10.4103/2230-8210.122652
PMID
:24381903
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Addendum: First injection technique recommendations for patients with diabetes, Forum for Injection Techniques India
Sanjay Kalra, Yatan Pal Singh Balhara, Manash P Baruah, Manoj Chadha, Hemraj B Chandalia, Subhankar Chowdhury, Jothydev Kesavadev, K. M. Prasanna Kumar, Sonal Modi, Shailesh Pitale, Shukla Rishi, Rakesh Sahay, Annamalai Sundaram, Ambika G Unnikrishnan, Subhash K Wangnoo
November-December 2013, 17(6):1005-1008
DOI
:10.4103/2230-8210.122611
The forum for injection techniques, India recommendation, the first ever in the country on insulin injcetion techniques, have covered the science and the art of insulin injection technique in an exhaustive manner. However, a few gaps were identified in the document, which are addressed in the current addendum. This article focuses on insulin injection technique in special clinical situations, including geriatric people, women in pregnancy and those with dermatological or surgical disease who live with diabetes. The addendum also covers salient features of administration of insulin using the insulin pump.
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