Close
  Indian J Med Microbiol
 

Figure 1: Leptin/Ob-Rb binding results in insulin receptor substrate (IRS) phosphorylation, which in turn activates PI3K/AKT pathway through the association of IRS with the regulatory subunit p85 of AKT. Activated AKT in turn phosphorylates XIAP (a member of antiapoptotic proteins) thus inhibiting its degradation, which leads to decreased caspase-3 activity and decreased apoptosis; PI3K: phosphoinositide-3-kinase; AKT: protein kinase B; XIAP: X-linked inhibitor of apoptosis protein; Bcl: base class library (adapted from Uddin S et al. Role of leptin and its receptor in the pathogenesis of thyroid cancer. Int J Clin Exp Pathol 2011;4:637-43)

Figure 1: Leptin/Ob-Rb binding results in insulin receptor substrate (IRS) phosphorylation, which in turn activates PI3K/AKT pathway through the association of IRS with the regulatory subunit p85 of AKT. Activated AKT in turn phosphorylates XIAP (a member of antiapoptotic proteins) thus inhibiting its degradation, which leads to decreased caspase-3 activity and decreased apoptosis; PI3K: phosphoinositide-3-kinase; AKT: protein kinase B; XIAP: X-linked inhibitor of apoptosis protein; Bcl: base class library (adapted from Uddin S et al. Role of leptin and its receptor in the pathogenesis of thyroid cancer. Int J Clin Exp Pathol 2011;4:637-43)