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  Indian J Med Microbiol
 

Figure 2: Leptin produced by cancer cells and adipocytes through ObRb activate JAK/STAT pathway and MAPK pathway which augments AP-1 expression which leads to increased CYP19A1 (aromatase) gene transcription leading to increased local estrogen production, thus augmenting estrogen signaling through ER-945;. Leptin in addition blocks ER-α proteosomal degradation. This ultimately results in increased proliferation of breast cancer cells; JAK: janus kinase; STAT: transducer and activator of transcription; MAPK: mitogen-activated protein kinase; AP-1: activating protein-1; ER: estrogen receptor (adapted from Sebastiano Andò and Stefania Catalano. The multifactorial role of leptin in driving the breast cancer microenvironment Nature Reviews Endocrinology 2012;8:263-25)

Figure 2: Leptin produced by cancer cells and adipocytes through ObRb activate JAK/STAT pathway and MAPK pathway which augments AP-1 expression which leads to increased CYP19A1 (aromatase) gene transcription leading to increased local estrogen production, thus augmenting estrogen signaling through ER-945;. Leptin in addition blocks ER-α proteosomal degradation. This ultimately results in increased proliferation of breast cancer cells; JAK: janus kinase; STAT: transducer and activator of transcription; MAPK: mitogen-activated protein kinase; AP-1: activating protein-1; ER: estrogen receptor (adapted from Sebastiano Andò and Stefania Catalano. The multifactorial role of leptin in driving the breast cancer microenvironment Nature Reviews Endocrinology 2012;8:263-25)